For more than 40 years, Bisphenol A, more commonly known as BPA, was used in everything from plastic baby bottles and the lining of metal food containers to dental sealants. When scientists began seeing a connection between BPA and abnormal sperm and egg development, it set off worldwide public health concerns. The types of abnormal development researchers detected could lead to increased cases of Downs and Klinefelter syndromes in children or to infertility.As more scientists began investigating the effects of toxicant exposure and links to abnormal fetal development, three University of Georgia researchers discovered a more efficient, accurate and cost-effective way to conduct these studies using cells in a petri dish. Franklin West and Steve Stice, animal scientists in the UGA College of Agricultural and Environmental Sciences, and Mary Alice Smith, a toxicologist in environmental health science in the UGA College of Public Health, began testing the efficiency of a technology West and Stice developed to measure the effects of environmental toxicants. They use cells that come from stem cells and represent the early cells that eventually will form sperm cells in adults. The cells are highly vulnerable to toxicants.Their findings were published recently in Toxicological Sciences.“There is no human system to study toxicant effects on early sperm development,” West said. “But, we can expose these human cells to different toxicants and predict how changes will impact birth defects and fertility later in life.”Currently, most developmental toxicological studies are done using mice or rats. “We need to move away from rodent tests because they often won’t tell us how detrimental or safe chemicals are in humans,” West said. “For example, the potential effects of BPA in humans, especially in the unborn child, is still hotly contested. This cell culture system moves us away from animal testing, which most agree is preferable as long as the studies are equally or more reliable.”The new testing model fills a void left by current methods and provides human-specific results.“Using animal studies, you are looking at more than a year to test a chemical in rodents,” Stice said. “Using this test, we get results in two to three weeks at most and possibly shorter.”Considering the vast number of untested chemicals humans are exposed to, with new ones coming out every day, animal testing will never be practical to prioritize which chemicals need further testing, Stice said. There are more than 80,000 chemicals in the environment that haven’t been tested for human impact mainly because of the cost and time required using current procedures.The reliability of those results also must be considered.“Mice don’t have three or four (of the) critically important genes that are leading causes of infertility,” West explained. “Sperm and egg cells are the only cells that go through meiosis, a special type of cell division necessary for sexual reproduction. You can’t use another type of cell to find the impact a chemical has on these cells and, in turn, fetal development.”West first developed the germ-like cells during his doctoral work in Stice’s UGA laboratory.“Our next step with the cells is to test more chemicals and see what happens with more compounds,” he said.Stice also plans to use neural and bone forming cells he developed to test chemicals for developmental neurological and skeletal toxicology. Scientists at the Environmental Protection Agency already have demonstrated in peer-reviewed studies that these types of cells are very sensitive to known toxins such as lead and mercury. The team is now testing more chemicals on these cells.“If the assay is predictive and repeatable, the chemical industry will have better, faster and less expensive test systems and, as a result, will reduce the use of animal testing and experiments,” Stice said.“Testing more known chemicals for developmental toxicology will validate these assays for later use by the chemical industry. Our shared long-term goal is to ensure the health and well being of our children,” he said.An abstract of the journal article is available at http://toxsci.oxfordjournals.org/content/129/1/9.
Indianapolis, In. — The American Association of Motor Vehicle Administrators (AAMVA) recently recognized the Indiana Bureau of Motor Vehicles (BMV) with a Visual Arts Award for their Real ID promotional logo. The logo asks the question, “Will Your License Fly?” and serves as a reminder for Hoosiers to upgrade to a Real ID by October 2020.A Real ID is indicated by a star in the upper-right corner of a license, permit or ID and meets security standards passed by federal legislation in 2005. As of October 1, 2020, anyone who does not have a Real ID-compliant license, permit or ID will not be able to board any domestic commercial airplane without a passport. Also, individuals without a Real ID cannot currently enter military bases and some federal facilities.To obtain a Real ID-compliant credential, applicants must bring documents to any BMV branch to prove their identity (name and date of birth), Social Security number, lawful status in the United States, and Indiana residency. Detailed information pertaining to Real ID and the documents required to upgrade can be found at REALID.in.gov.The BMV also received three service awards from AAMVA. The awards recognize projects and services conducted in 2017 to benefit Hoosiers and the motor vehicle and law enforcement communities.A Regional and International Community Service Award for an agency-wide food drive conducted in 2017. The food drive donated nearly 24,000 items to community food pantries throughout the state.A Regional and International Service Award for Innovative Use of Technology. The BMV received this award for their initiative to bring a BMV Connect center to Fort Wayne’s Pine Valley Branch.A Regional Excellence in Government Partnership Award for the agency’s role in the development of the Indiana Coalition on Automated Vehicles.AAMVA is a non-profit organization developing model programs in motor vehicle administration, law enforcement, and highway safety. Their awards program fosters a tradition of excellence in the motor vehicle and law enforcement community by honoring individuals, teams, and organizations who have committed their time and resources to safety initiatives, outstanding customer service, and public affairs and consumer educational programs throughout North America.
RelatedPosts Israel Adesanya in tears on UFC debut UFC: Israel Adesanya plans 42-year-old man fight Israel Adesanya expects Whittaker rematch Nigeria’s Israel Adesanya defeated Yoel Romero by unanimous decision to retain his middleweight championship in Saturday night’s main event at UFC 248 at T-Mobile Arena in Las Vegas. The judges scored the bout 48-47, 48-47 and 49-46. The first two rounds featured very few exchanges between the fighters, but Romero appeared to have the two most significant strikes in the opening 10 minutes, including an overhand left that appeared to hurt Adesanya’s eye in the first. Adesanya picked up the pace in Round 3, especially with his kicks, landing one to the body and several sharp leg kicks. He also landed the most significant strike in the fourth round, another hard leg kick that briefly buckled Romero. Adesanya continued to do damage with hard leg kicks in the final round, and Romero’s right thigh had visible welts by the end of the fight. Adesanya (19-0) was making the first defence of his undisputed middleweight title, which he captured when he knocked out Robert Whittaker at UFC 243. He entered that fight as the interim champion and unified the crown with the win. With Sunday’s win, Adesanya became only the fourth middleweight in UFC history to begin his career 8-0 with the promotion, joining Anderson Silva, Chris Weidman and Romero. Romero (13-5) has lost four his past five fights, including three defeats in title bouts. In his previous fight, he lost a hard-fought unanimous decision to Paulo Costa at UFC 241 in August. Romero was slotted in Sunday’s fight because of an injury to Costa. Adesanya entered the fight as ESPN’s No. 7-ranked pound-for-pound fighter in the world. Romero is ESPN’s No. 4 middleweight.Tags: Israel AdesanyaYoel Romero
Virginia Lee (Reed) Stamm was born October 11, 1946 at Caldwell to Hugh and Betty (Claypole) Reed. Virginia died on Friday, June 7, 2013 at Haysville. She was 66 years old.Virginia enjoyed the outdoors, fishing, camping, flowers and spending time with her family.She was preceded in death by her grandparents, and her parents Hugh and Betty Reed and brother Billy Reed.Her survivors include three daughters; Tammy Longbrake of Goddard, Tina Stamm of Van Buren, Arkansas, Misty Buchanon of Wichita; one son Terry Stamm of Wellington; three brothers; Tom Reed of South Haven, Larry Reed of Anthony, Jim Reed of Arkansas City; two sisters Ruth Mark of Attica, and Mary Lou Mort of Arkansas City; seven grandsons, four granddaughters, and three great-grandsons.A graveside service will be held 10:00 a.m. Tuesday, June 11, 2013, at Goodel Cemetery, Drury.To share a memory or leave a condolence please visit www.schaeffermortuary.info Arrangements by Schaeffer Mortuary, 6 N. Main, Caldwell.
Mickey Harte has made two changes to the Tyrone team to face Donegal in Sunday’s mouth-watering Ulster Football Championship semi-final in Clones.The anticipation to the game is now white hot with many feeling Sunday’s clash will be the ultimate test to see how far the new-look Donegal side has really come.The Tyrone boss has admitted Donegal are the in-form side but will have done his homework on ways of dismantling McGuinness’ team. Joe McMahon comes into the Tyrone team following a lay off due to a broken jaw sustained while playing for his club Omagh St Enda’s in a club match in April.He replaces Cathal McCarron, with Kevin Hughes taking over from for Aidan Cassidy, who suffered an ankle injury in a recent club outing.Donegal boss Jim McGuinness is in the unlikely position of having an injury-free panel to choose form.The only dilemma he would appear to have it whether to play Glenfin man Frank McGlynn from the start now that he is back to full fitness. The Tyrone team is – Pascal McConnell , Martin Swift , Joe McMahon, Ryan McMenamin , Davy Harte, Conor Gormley, Philip Jordan, Kevin Hughes, Sean Cavanagh, Brian Dooher, Brian McGuigan , Peter Harte, Martin Penrose , Stephen O’Neill , Mark DonnellySubs: John Devine, Aidan Cassidy, Colm Cavanagh, Kyle Coney, Cathal McCarron, Damian McCaul, Aidan McCrory, Tommy McGuigan, Justin McMahon , Owen Mulligan, Sean O’NeillHARTE MAKES TWO CHANGES TO TEAM AS COUNTDOWN TO ULSTER SEMI-FINAL REACHES CLIMAX was last modified: June 23rd, 2011 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Jim McGuinnessmickey harteUlster Championship semi-final