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Irish players to tee off in Portugal Masters

first_imgMichael Hoey, Paul Dunne, Damian McGrane, Padraig Harrington and Peter Lawrie are all involved.Europe’s Ryder cup captain Darren Clarke is part of the field.Padraig Harrington has played in 6 Ryder Cups, winning 4. He says consistency is the key for those hoping to be involved at Hazeltine next year.Meanwhile, the new PGA season gets underway in the Napa Valley later today. Rory McIlroy will play alongside Justin Rose and Brandt Snedeker for the opening rounds of the Frys-dot-com Open.last_img read more

Clippers hiring Tyronn Lue as Doc Rivers’ top assistant coach, report says

first_imgTyronn Lue is returning to the NBA. The Clippers are hiring Lue as the team’s top assistant coach under Doc Rivers, according to a report from The Athletic, which cites unidentified league sources. Lue previously worked on Rivers’ staff with the Celtics from 2011-13 and with Los Angeles in 2013-14.  The New York Times reported last week the sides were close to an agreement.Former Cavaliers championship coach Ty Lue has agreed on deal to join the Los Angeles Clippers as the top assistant coach on Doc Rivers’ staff, league sources tell @TheAthleticNBA @Stadium.— Shams Charania (@ShamsCharania) August 21, 2019Lue will be joining a team with high expectations heading into 2019-20. The Clippers retooled their roster this offseason as they signed star Kawhi Leonard in free agency and acquired Paul George in a blockbuster trade with the Thunder.  Related News Clippers, Steve Ballmer unveil plan for potential multi-billion dollar, privately funded arena Kawhi Leonard says he was ‘very close’ to choosing Lakers, Raptors over Clippers NBA free agency news: Patrick Patterson signs 1-year deal with Clippers “I grew up a Clippers fan,” Leonard said during his introductory press conference. “I loved the Clippers as a kid. With Doc (Rivers) being a championship head coach, that is something I wanted, an experienced coach. And the front office is very transparent with me. They want to win. It’s an opportunity for us to build our own (thing) and make history.”Lue has been out of the league since he was fired by the Cavaliers in early October after an 0-6 start to the season. He registered a 128-83 record and won a championship during his time as Cleveland’s head coach.  Lue was reportedly close to joining the Lakers as their head coach and reuniting with LeBron James this summer. But, those negotiations fell apart and the Lakers eventually hired Frank Vogel.last_img read more

Tesla Model 3 Dashcam Captures Camaro Driver Smashing Into A Tesla


Junk DNA may help yeast survive stress

first_img ‘Junk DNA’ may help yeast survive stress Sign up for our daily newsletter Get more great content like this delivered right to you! 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Required fields are indicated by an asterisk (*) Steve Gschmeissner/Science Source center_img Yeast may rely on introns to help them survive hard times. Email Like deleted scenes snipped out of a movie, some sequences in our genes end up on the cutting-room floor, and cells don’t use them to make proteins. Now, two studies find that these segments, known as introns, help yeast survive during hard times. The research uncovers another possible function for a type of DNA that scientists once thought was useless.“They are very strong, very convincing, and very exciting results,” says evolutionary molecular biologist Scott Roy of San Francisco State University in California, who wasn’t connected to the studies. The research “opens a whole new paradigm of what introns could be doing.” It also answers the long-standing question of why yeast has kept what was formerly considered “junk DNA,” says yeast microbiologist Guillaume Chanfreau of the University of California, Los Angeles.Introns are prevalent in plants and fungi, as well as in humans and other animals—each of our roughly 20,000 genes carries an average of eight. When one of our cells starts to make a protein from a particular gene, enzymes generate an RNA copy that includes the introns. Next, the cell snips the introns out of the RNA and splices the remaining portions of the molecule back together. This edited RNA molecule then serves as a guide to build the protein. Removing introns requires a lot of energy—and a complex set of molecular shears—suggesting the sequences evolved to carry out specific functions. After initially dismissing them as junk, researchers have recently begun to identify some of these roles. For instance, introns in some genes may help control how much of the corresponding proteins the cell manufactures.But in baker’s yeast, an organism that has ditched most of its introns (it has just 295 for some 6000 genes), the functions of most of the sequences are murky. Scientists who deleted individual introns, for example, found that in most cases the fungi were unfazed.However, researchers typically haven’t looked at yeast under conditions it would face in the wild, where it could endure periods of food scarcity that don’t occur in the lab. To determine what happens during deprivation, RNA biologist Sherif Abou Elela of the University of Sherbrooke in Canada and colleagues systematically deleted introns from yeast, producing hundreds of strains, each of which was missing all of the introns from one gene. The researchers then grew combinations of these modified strains alongside normal fungi.When food was scarce, most of the intron-lacking strains rapidly died out, the team reports today in Nature. They couldn’t compete with normal yeast. However, in cultures with more nutrients, the altered yeast had the advantage. “If you are in good times, it’s a burden” to have introns, Abou Elela says. “In bad times, it’s beneficial.”Molecular biologist David Bartel of the Massachusetts Institute of Technology in Cambridge and colleagues independently chanced on similar results. They were measuring the amounts of different RNA molecules in yeast cells, and they expected most introns to quickly deteriorate after they were snipped out of their parental RNA strand. But as they report today in a separate paper in Nature, they noticed that large numbers of introns built up in cells growing in crowded cultures.“It was incredibly bizarre,” says Bartel’s former graduate student Jeffrey Morgan, now a molecular biologist at the University of Utah in Salt Lake City. Like Abou Elela’s team, Bartel’s group found that introns aided yeast under duress but harmed cells living under more favorable conditions. The scientists suspect the introns help the stressed-out yeast rein in growth.Although how these introns provide their benefits remains unclear, the two studies suggest similar mechanisms. As the yeast’s environment turns harsh, introns become more abundant and may effectively clog the molecular shears that normally snip them out of RNAs, slowing down the synthesis of some proteins and allowing the cells to conserve their resources. That may seem like a convoluted process, but “evolution doesn’t always choose the simplest solution,” Bartel says.last_img read more