Jan 12, 2006 (CIDRAP News) – An H5N1 avian influenza virus recovered from a Turkish patient has a mutation that may enable the virus to spread more easily from birds to humans, though the finding’s significance for human health is not yet clear, the World Health Organization (WHO) reported today.Viruses recovered from the first two Turkish children to die of avian flu have been analyzed in London, the WHO said. A sample from one of the patients has a mutation at “the receptor-binding site,” a reference to hemagglutinin, a protein that enables flu viruses to attach to and enter host cells.”One of the mutations has been seen previously in viruses isolated from a small outbreak in Hong Kong in 2003 (two cases, one of which was fatal) and from the 2005 outbreak in Viet Nam,” the WHO said. “Research has indicated that the Hong Kong 2003 viruses bind preferentially to human cell receptors more so than to avian cell receptors. Researchers at the Mill Hill [London] laboratory anticipate that the Turkish virus will also have this characteristic.”What the finding may mean for human health will depend on clinical and epidemiological data now being gathered in Turkey, the agency said. It added that it has found no evidence of sustained person-to-person transmission of the virus in any country so far.In a Washington Post report today, the WHO’s Michael Perdue called the finding “a little concerning because the virus is still trying new things in its evolution.” Perdue is overseeing the WHO’s response to the Turkish outbreak from agency headquarters in Geneva, the story said.The WHO statement did not suggest whether the mutation could be a factor in the rapid increase in reported human cases in Turkey since the first two were revealed Jan 4. The number reached 18 today with the report that three more Turkish children have tested positive for an H5 avian flu virus, a finding that usually points to H5N1. The tests were done in a Turkish lab.The cases include two children, aged 4 and 6, in Sanliurfa province in southern Turkey and in Siirt province in the east, the WHO reported. Both had contact with sick birds. The other patient was a 12-year-old girl who died Jan 7 in eastern Turkey and was the sister of two teenagers who died of avian flu earlier.The WHO so far has officially recognized just four cases in Turkey on the basis of confirmation by outside labs.The analysis by the British lab showed that the viruses from the two Turkish children were very similar to H5N1 viruses recovered from birds in Turkey, the WHO said. The viruses were also closely related to viruses isolated from migratory birds that died at the Qinghai Lake nature reserve in China last spring.The WHO said the studies also indicate that the Turkish viruses are sensitive to both classes of antiviral drugs used against flu: oseltamivir (a neuraminidase inhibitor) and amantadine (an adamantane). H5N1 viruses are usually described as insensitive to adamantanes, though some strains have been susceptible.”WHO and collaborating experts will review the data on amantadine sensitivity. Oseltamivir remains the drug of first choice recommended by WHO,” the agency said.The agency said its pandemic alert level is still in phase 3: “human infections with a new virus subtype are occurring, but the vast majority of these infections are acquired directly from animals.”See also:Jan 12 WHO news releasehttp://www.who.int/csr/don/2006_01_12/en/index.html
Property developer Sinar Mas Land, through PT Bumi Serpong Damai, has formed a partnership with Singapore-based Mitbana Pte Ltd to build transit-oriented developments (TODs) in BSD City, South Tangerang, Banten.Mitbana, established in March 2019, is a joint venture company of Mitsubishi Corporation from Japan and Surbana Jurong from Singapore.“With this commitment, Mitbana will become Sinar Mas Land’s largest development partner in BSD City, and we look forward to having our partnership bring even better value to our residents and becoming a model for TOD developments in Indonesia,” said Sinar Mas Land group chief executive officer Michael Widjaja.Mitbana will work with Sinar Mas Land to transform over 100 hectares of greenfield land in BSD City into TODs comprising residential units, commercial properties, living amenities and public transport nodes. This undertaking will enlarge BSD City’s existing development footprint and expand on its current population of 200,000 residents, Sinar Mas said in a statement. According to data from the Investment Coordinating Board (BKPM), Singapore was Indonesia’s top foreign investor in the first half of 2020, with a total of US$3.4 billion in realized investments comprising 5,348 projects. During the same period, Japan was the second-largest with investment of US$2.4 billion comprising 3,708 projects, the statement read.Mitbana CEO Gareth Wong said, “The future growth potential of TODs in Indonesia presents many scalable development opportunities for Mitbana, and we are very excited to make this first step toward realizing our vision of becoming a leading urban development fund that transforms communities through smart, sustainable and social development thrusts.”BSD City is Sinar Mas Land’s flagship town development that encompasses a total land area of approximately 6,000 hectares.Topics :
Yesterday, Baylon filed a string ofcharges against Baylen – direct assault, trespass to dwelling and physicalinjury. Police Major Jess Baylon surrenderedto the Cabatuan police station after shooting Dennis Baylen, 27. ILOILO City – The chief of Malay,Aklan’s police station was jailed for shooting the nephew of his wife inBarangay Tinio-an, Cabatuan, Iloilo on Tuesday night. Moments later Baylen returned andpelted Baylon’s house with stones. “What I did was only to protect myfamily. Take note that the incident happened inside my compound. I took a leaveof absence to be with my son on his birthday. Dennis interrupted ourcelebration,” said Baylon./PN The police officer said he stoppedBaylen and told him to go home; on the other hand, he decided to let the uncleinside his house. The shooting happened at around 10p.m. A stone hit Baylon’s wife unconscious. After shooting Baylen, Baylon alertedthe Cabatuan police and surrendered. He also gave up his service firearm. Baylen, on the other hand, filed anattempted homicide complaint against Baylon. “I did not have the intention to killhim. I only wanted to neutralize him,” said Baylon. He said Baylen was unruly, armed withstones and a bottle and tried to harm his (Baylon) family. Prior to it, Baylon said, a drunkenBaylen mauled an uncle, Lambert Baylen, in front of his (Baylon’s) house. The unruly Baylen tried to enter thehouse thus, Baylon said, he shot the suspect on both legs.
Lately I have been running into a lot of old friends and acquaintances from my years as a high school coach. At several track meets this past season two starters who were working when I was a head track coach are still in the business of starting track meets. Rodney King does a lot of meets in this area now since he is retired from his regular job. He always was, and still is, a good starter. He makes young athletes feel at ease, and this cuts down on annoying false starts.What really surprised me was running into Joe Edmunds at the boys regional in Connersville. Joe and I go back to my early days as a beginning teacher in the Northeastern School System in the 60’s. It was known as Williamsburg when I taught there. Joe works mainly north of Interstate 70, so I had not seen him in the past several years. Joe, like Rodney, enjoys being with young athletes, and that makes him a good starter as well.I have already talked about some of our local starters, and as I previously stated, if other sports in Indiana were like track and cross country, you would hear a lot less complaining about officials.
The defending champion laid waste to Augusta National yesterday as he carded a faultless round of 66 to hold a two-shot cushion on 6-under par.But Shane Lowry is right on the coat-tails of the world number two.Lowry holds a share of second place on 4-under par after brilliant round of 68 that leaves him alongside Dany Lee. Rory McIlroy bogeyed two of his final three holes in the tough scoring conditions last night to sit on 2-under par.Of the other two Irish players, Graeme McDowell is on level-par while Darren Clarke is facing a tough day when he resumes from 4-over par – the European Ryder Cup captain will be the first Irish player to tee-off once-again today when he returns to the course just before quarter-to-two.