Captain material 😂— Usismama (@Usismamayo) July 23, 2019More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing Arsenal 1/1 Read More SPONSORED 1 min. story Rio Ferdinand tells Ole Gunnar Solskjaer to drop Top articles Rob Holding refused to sign a Tottenham shirt while on Arsenal’s pre-season tour of America (Picture: Arsenal Twitter)Arsenal fans believe Rob Holding has announced himself as an ideal candidate to succeed Laurent Koscielny as club captain after he refused to sign a Tottenham shirt during the pre-season tour of America.The 23-year-old impressed during the first half of last season, cementing a place in Unai Emery’s starting XI before he suffered a cruciate knee ligament injury following a clash with Marcus Rashford last November.Arsenal are hopeful the former Bolton defender will have recovered in time to make his first team return by the end of September which would represent a welcome boost given the uncertainty surrounding Koscielny’s future and Emery’s failure thus far to sign a new centre-half this summer.AdvertisementAdvertisement‘When he decided not to come here with us on tour, the solution is now only for the club and him,’ Emery said following last night’s penalty shootout defeat against Real Madrid. ‘He decided to be out.ADVERTISEMENT Skip Coming Next Read More My captain— gunners guru 19 (@GuruGunners) July 23, 2019 by Metro Read More Comment Read More CAPTAIN HIM RIGHT NOW— Jack Simmons (@JackSimmons101) July 23, 2019 PLAY Visit Advertiser website GO TO PAGE Advertisement / About Connatix V67539 Metro Sport ReporterWednesday 24 Jul 2019 2:43 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link2.4kShares Video Settings Full Screen More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man City‘I respect him but I have a responsibility, he has a responsibility, and the club have their responsibility. Now it’s an issue only for the club and him.‘My idea is to continue with the players we are working with, and the players that want to be here.’Koscielny’s likely departure will leave something of a leadership vacuum at Arsenal, but many Gooners believe Holding it capable of stepping into the breach after turning down a request to put his moniker to a Spurs shirt…Just give him the armband.— ❄ (@AmaechiSZN) July 23, 2019 Read More struggling Manchester United captain Harry… ‘Give him the armband’ – Rob Holding refuses to sign Tottenham shirt and Arsenal fans love it Advertisement Skip Ad
The USC men’s basketball team was unable to put an end to its four game losing streak on Wednesday night, falling to the UCLA Bruins (15-11, 8-6) by a score of 64-54. The Trojans (6-21, 1-13) dropped their fifth straight game and are just 1-14 in their past 15 contests.Tough break · Without the services of redshirt junior forward Aaron Fuller, who was lost earlier in the season to a torn shoulder injury, the Trojans went 1-8. USC will look for its second conference victory next Thursday at Arizona. – Luciano Nunez | Daily TrojanUSC returned to its former homecourt, the Los Angeles Sports Arena, for the first time since 2006 to face off against its crosstown rivals. UCLA is making repairs to the Pauley Pavilion and has been using the arena as its venue for the season.“That’s a good team there,” USC coach Kevin O’Neill said of the Bruins. “They were picked 12th nationally and to win our league. I think you have to take into consideration that they haven’t played a home game all year. These guys have been forced to play at a neutral site every single game.”The Bruins jumped out to an early advantage over the Trojans, starting the game on a 10-2 run. USC struggled shooting the ball in the first half, finishing 7-29 (24 percent) compared to UCLA’s 14-27 (52 percent). They trailed going into the break, 31-16.“It comes down to shot-making with us,” O’Neill said. “We didn’t make any shots in the first half and shot 39 percent for the game.”USC outscored the Bruins in the second half by a five-point margin — 38-33 — but couldn’t fully recover from an early deficit. Still, the Trojans managed to avoid another blowout at the hands of UCLA, as was the case on Jan. 15 in a 66-47 loss.“We approach every game the same, we just took a different type of initiative to not fold and to keep fighting,” sophomore guard Maurice Jones said.Freshman guard Byron Wesley led the Trojans with 16 points and seven rebounds, shooting 5-11 from the floor and 6-10 from the free throw line. He earned high praise from O’Neill for his performance.“I think he’s becoming a really legit [player],” O’Neill said. ‘We want him to be aggressive to the basket.”Also joining Wesley in double figures was sophomore forward Garrett Jackson, who added 15 points, four steals and three blocks.The Bruins, meanwhile, were paced by twin forwards David and Travis Wear, who contributed a combined 30 points and 24 rebounds.“They’re really, really good players,” O’Neill said. “They’re only redshirt sophomores, they’ve both got two years left to play … Their frontline is as good as anyone’s in the country other than North Carolina probably.”The Trojans will get their longest break of the season —eight days — before traveling to Arizona to take on the Wildcats (18-8, 9-4) on Feb. 23.The Wildcats have won four straight games, including road victories against Stanford and the Pac-12 leading California.In their first meeting on Jan. 8, USC fell to Arizona at the Galen Center by a score of 57-46. USC has four games remaining this season before the Pac-12 tournament.“Just getting some rest is going to help,” Jones said. “We only play about six, seven guys playing 20-30 minutes apiece. That’s the most important thing as we try to get these last four games.”
NBA trade deadline: 76ers send Markelle Fultz to Magic for Jonathon Simmons, draft picks Wishing you the best, Enes. pic.twitter.com/OajT463n3V— NEW YORK KNICKS (@nyknicks) February 7, 2019The Knicks have been trying to move Kanter for a few weeks, but his contract made things difficult, according to the initial report by ESPN. Kanter has an $18.6 million expiring deal.Kanter recently said he was unhappy with his smaller role with the team and that he’s “very disappointed” with coach David Fitzdale’s decision to keep him out of the rotation. Related News Enes Kanter’s time with the Knicks has come to a close.New York released the center Thursday, shortly after the NBA’s trade deadline had passed. Kanter appeared in just three of the Knicks’ last 12 games. One of the main reasons is the Knicks are trying to develop their younger players while also utilizing DeAndre Jordan, who New York acquired in a blockbuster trade with the Mavericks that sent Kristaps Porzingis to Dallas. NBA trade deadline: Grizzlies acquire Avery Bradley from Clippers for two players The Knicks’ abysmal record (10-43), along with the talk of releasing Kanter, had prompted fans at some home games to chant “We want Kanter!””I don’t know if the organization wants to hear that every game because it’s a little embarrassing,” Kanter said recently of the chants. “Because after all this [Porzingis] trade and everything that the fans still want me to go out there and play. I don’t know if they wanna hear that chant every game.”Kanter is averaging 14 points and 10 rebounds in 26 minutes per game this season.
A dramatic game between Final Four contenders Letran and Lyceum ended in the most anticlimactic of ways after game officials huddled together for a review of a call after the buzzer.ADVERTISEMENT Allen Durham still determined to help Meralco win 1st PBA title Although the game ultimately fell into the hands of the referees in a controversial decision, the match itself was a pulsating affair that saw the two teams slug it out in the final quarter.Marcelino almost traveled on his spin attempt but was able to get up for a layup that gave Lyceum a 75-73 lead that Bong Quinto quickly erased with a literal falling down shot that tied it at 75-75.Quinto would then work his magic twice more with his drives, giving the Knights an 80-77 lead with just two minutes left.“The players gave it their all, it was all out all heart, I can’t say anything aside from that they gave it their all,” said Napa. “The kids are the ones laying it out on the line and I’m just here to guide them, teach them what’s right and tell them the things they’re not supposed to do. The good intention became good execution.”Larry Muyang finished with a 23-point, 16-rebound double-double for Letran while Quinot delivered 20 points seven rebunds, and four assists.ADVERTISEMENT Tim Cone, Ginebra set their sights on elusive All-Filipino crown Nadine Lustre’s phone stolen in Brazil Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Osaka into China Open semifinals with win over Zhang LATEST STORIES Sports Related Videospowered by AdSparcRead Next Gretchen Barretto’s daughter Dominique graduates magna cum laude from California college Phivolcs: Slim probability of Taal Volcano caldera eruption Japeth Aguilar embraces role, gets rewarded with Finals MVP plum JP Calvo played his part as the Knights’ floor general 18 points, four boards, and six assists.Mike Nzeusseu led all scorers with 25 points with 10 rebounds while CJ Perez had 16 points and eight boards. The Knights came away with a 80-79 win over the Pirates after referees ruled Jaycee Marcelino’s field goal with 40.8 seconds left in the game was a long two instead of a three, which was the initial judgment.Marcelino’s field goal initially tied the game at 80 but it was later deemed a two after the review that was conducted at the end of regulation instead of during the dead ball situations after the shot was made.FEATURED STORIESSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSJapeth Aguilar wins 1st PBA Finals MVP award for GinebraSPORTSGolden State Warriors sign Lee to multiyear contract, bring back ChrissStill, it was a win the Knights badly needed as they improve to an 11-4 record to stay at the third seed while the Pirates settled at the second spot with a 14-2 slate.“Good win or big win for us? I don’t know but we won it’s that simple,” said Letran head coach Jeff Napa in Filipino. For the complete collegiate sports coverage including scores, schedules and stories, visit Inquirer Varsity. View comments Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Gov’t to employ 6,000 displaced by Taal Don’t miss out on the latest news and information. MOST READ Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew
Special Statement to the Nation by President Ellen Johnson Sirleaf, Delivered Sunday, November 16, 2014 My fellow Liberians: Even as we continue to combat the Ebola virus and strive to achieve our national objective of zero-new-cases by Christmas, we must also attend to what will be a difficult job of recovery – recovery to the health care system so that we deliver health care services all across the country and are better prepared for any epidemic of the size and scale of Ebola; recovery to the economy so that we are repositioned to produce more opportunities and afford decent and better living conditions for all our people; recovery to governance so that notwithstanding the superficial differences which haunt the body politic, we can still remain enjoined behind the common purpose of national healing and reconstruction. This requires a team that is adaptable, responsive, disciplined, loyal, and focused – a team that is understanding of the prevailing challenges, and are resolved to respond by taking appropriate risks to get things done on time. It is my job to continuously vet and ready such a team for the challenges we currently face and those that lie ahead. And so today, I announce a number of changes to the Executive Branch of the Government. A few are transferred or reassigned, signifying our recognition of their capabilities and performance. Others are dropped from where they served, but will be given appropriate opportunities to continue to serve the country. I am deeply grateful for the services and contribution of all of those we who have served or continue to serve. We are not short on expectation that going forward, each working day – indeed each working hour – will be spent not only on catching up and continuing with the transformational agenda of the country but also to exploring creative new approaches by which we deliver on the agenda within the limited time of our stewardship. My hope is that this team will take us to the finish line. But make no mistake: As Captain, I will not hesitate to change anyone who fails to meet our expectations. With these remarks, I am pleased to make the following initial appointments, others to follow at a subsequent time: Ministry of Public Works Mr. William Gyude Moore, Minister Mr. Roland Giddings, Deputy Minister for Administration Ministry of Education Dr. Elizabeth Davis-Russell, Minister Dr. Nancy Freeman, Deputy Minister for Administration Mr. Anthony Nimely, Deputy Minister for Planning, Research and Development National Investment Commission Mrs. Etmonia David Tarpeh, Chairperson Ministry of Health Mr. George Werner, Minister Ministry of Gender, Children & Social Protection Mrs. Julia Duncan-Cassell, Minister Mr. Peter Roberts, Deputy Minister for Administration Mrs. Sienne Abdul-Baki, Deputy Minister for Gender Mrs. Mardia Martin Wiles, Deputy Minister for Policy, Planning & Technical Services Mrs. Lydia Sherman, Deputy Minister for Children and Social Protection Ministry of Foreign Affairs Dr. Wede Brownell, Deputy Minister for Administration Ms. Albratha Doe, Assistant Minister for Foreign Affairs Ministry of Transport Mr. Bushuben M. Keita, Deputy Minister for Administration Ministry of Commerce & Industry Mr. Cyril Allen, Jr., Deputy Minister for Commerce Mr. Mohammed Turay, Assistant Minister for Industry National AIDS Commission Ms. Candace Eastman, Commissioner (replacing Ms. Wessehdi Sio-Njoh) Ministry of Youth & Sports Mr. Ramses Kumbuyah, Deputy Minister for Administration (replacing Ms. Jacqueline Capehart) Ministry of Lands, Mines & Energy Mr. Zack Sharpe, Deputy Minister for Administration Ministry of Information Mr. Andrew Tehmeh, Deputy Minister for Administration (to replace Norris Tweah who moves on to the University of Liberia) Ministry of Internal Affairs Ms. Gbemie Horace Kollie, Deputy Minister for Operations (replacing Mr. Ranney Jackson) Ministry of Posts and Telecommunications Ms. Margretta Smith-General, Assistant Minister for Administration (replacing Mr. James Cooper) Liberia Broadcasting System Mr. Ledgerhood Rennie, Director General Mr. Patrick Honnah, Deputy Director General for Broadcasting Mr. Christopher Sellee, Deputy Director General for Rural Comms The special word on the change in the Ministry of Health. Dr. Gwenigale will continue to serve as Advisor until his planned retirement in February.Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)
Jul 6 2018Faced with the epidemic of opioid addiction, researchers have been charged with finding other strategies to treat pain. Their efforts largely have focused on nerve cells that transmit pain signals to the spinal cord and brain. But new research, led by scientists at Washington University School of Medicine in St. Louis, shows that targeting receptors on immune cells may be more effective, particularly for chronic pain.Recently, a non-opioid, investigational drug called EMA401 has shown promise as a treatment for lingering nerve pain following shingles infection. While trying to understand how that drug helped control pain, the Washington University research team was surprised to find that it doesn’t hit nerve cells; rather, it targets a receptor on immune cells.Their findings are published July 2 in The Journal of Neuroscience.”We are in dire need of good pain-killing drugs, particularly non-opioid drugs,” said principal investigator D.P. Mohapatra, PhD, an associate professor in anesthesiology. “Generally, scientists have the understanding that targets for treating pain must be within the nervous system. It turns out that the target here is not on nerve cells, but on immune cells called macrophages.”The investigational drug inhibits the angiotensin II type 2 receptor that is targeted by medications that lower blood pressure. Angiotensin is a hormone that causes blood vessels to constrict, increasing blood pressure.This drug was thought to work by interacting with the type 2 receptor on nerve cells -; the same cells that carry pain signals. But when Mohapatra and his colleagues at the Washington University Pain Center looked more closely, they found that theory was wrong.”When we took nerve cells from mice, put them in a culture dish and added the angiotensin hormone, nothing happened,” said co-investigator Andrew Shepherd, PhD, an instructor in anesthesiology. “There was no angiotensin type 2 receptor on sensory neurons, so pain signals couldn’t be transmitted.”Related StoriesMarijuana isn’t a great choice for glaucoma treatment, says expertHow a simple MRI scan can help patients with anginaNew computational model explores daily pain sensitivity rhythmsBut in other experiments in which they injected the angiotensin hormone into mice, the animals indicated they felt pain and withdrew their paws when touched.”We found that the receptor the drug affected wasn’t on the nerve cells; it was on macrophages, the immune cells,” Shepherd said. “When we added macrophages to the dish alongside the nerve cells, the angiotensin could ‘talk’ to the macrophages, and then the macrophages ‘talked’ to the nerve cells, which then transmitted pain signals.”When the researchers reduced the number of macrophages in mice, the animals didn’t appear to feel pain in response to an angiotensin injection. But as the macrophages repopulated over the course of a few days, the response to pain returned. To support these observations in mice and the culture dish, the researchers also have found increased numbers of macrophages alongside degenerating nerve fibers in skin biopsies taken from the legs of patients who have diabetic neuropathy.Increasing the number of potential targets for painkillers and including targets such as receptors on immune cells may make it possible to develop more effective painkilling drugs with fewer side effects, Mohapatra said.”The beauty of this drug is that, unlike an opioid, it doesn’t cross the blood-brain barrier, so right away you eliminate a number of potentially harmful side effects, including addiction and the potential for abuse,” he said. “And by widening the scope of potential targets to macrophages, it may be possible to develop more effective therapies for chronic, neuropathic pain.” Source:https://medicine.wustl.edu/news/targeting-immune-cells-provides-non-opioid-pain-relief-in-mice/