Jan 12, 2006 (CIDRAP News) – An H5N1 avian influenza virus recovered from a Turkish patient has a mutation that may enable the virus to spread more easily from birds to humans, though the finding’s significance for human health is not yet clear, the World Health Organization (WHO) reported today.Viruses recovered from the first two Turkish children to die of avian flu have been analyzed in London, the WHO said. A sample from one of the patients has a mutation at “the receptor-binding site,” a reference to hemagglutinin, a protein that enables flu viruses to attach to and enter host cells.”One of the mutations has been seen previously in viruses isolated from a small outbreak in Hong Kong in 2003 (two cases, one of which was fatal) and from the 2005 outbreak in Viet Nam,” the WHO said. “Research has indicated that the Hong Kong 2003 viruses bind preferentially to human cell receptors more so than to avian cell receptors. Researchers at the Mill Hill [London] laboratory anticipate that the Turkish virus will also have this characteristic.”What the finding may mean for human health will depend on clinical and epidemiological data now being gathered in Turkey, the agency said. It added that it has found no evidence of sustained person-to-person transmission of the virus in any country so far.In a Washington Post report today, the WHO’s Michael Perdue called the finding “a little concerning because the virus is still trying new things in its evolution.” Perdue is overseeing the WHO’s response to the Turkish outbreak from agency headquarters in Geneva, the story said.The WHO statement did not suggest whether the mutation could be a factor in the rapid increase in reported human cases in Turkey since the first two were revealed Jan 4. The number reached 18 today with the report that three more Turkish children have tested positive for an H5 avian flu virus, a finding that usually points to H5N1. The tests were done in a Turkish lab.The cases include two children, aged 4 and 6, in Sanliurfa province in southern Turkey and in Siirt province in the east, the WHO reported. Both had contact with sick birds. The other patient was a 12-year-old girl who died Jan 7 in eastern Turkey and was the sister of two teenagers who died of avian flu earlier.The WHO so far has officially recognized just four cases in Turkey on the basis of confirmation by outside labs.The analysis by the British lab showed that the viruses from the two Turkish children were very similar to H5N1 viruses recovered from birds in Turkey, the WHO said. The viruses were also closely related to viruses isolated from migratory birds that died at the Qinghai Lake nature reserve in China last spring.The WHO said the studies also indicate that the Turkish viruses are sensitive to both classes of antiviral drugs used against flu: oseltamivir (a neuraminidase inhibitor) and amantadine (an adamantane). H5N1 viruses are usually described as insensitive to adamantanes, though some strains have been susceptible.”WHO and collaborating experts will review the data on amantadine sensitivity. Oseltamivir remains the drug of first choice recommended by WHO,” the agency said.The agency said its pandemic alert level is still in phase 3: “human infections with a new virus subtype are occurring, but the vast majority of these infections are acquired directly from animals.”See also:Jan 12 WHO news releasehttp://www.who.int/csr/don/2006_01_12/en/index.html
HAYS, Kan. – After last week’s three races in six days, the United Rebel Sprint Series will next head this Saturday and Sunday, July 14 and 15 to the 10th running of the Wheatshocker Nationals at RPM Speedway in Hays, Kan., for their opening weekend of the Ellis County Fair.Oklahoma’s Andy Shouse took home top honors in last years event, collecting the $2000 winner’s share and also taking home the custom Pit Boss Pellet Grille furnished by Lance Pittmann of S&W Supply/Federated Auto Parts of Hays for being the top point earner of the two-day event.This year’s event will once again pay $2,000 to the winner with $200 to start in Saturday’s championship feature. Pittman will once again furnish a custom Pit Boss Pellet Grille to the overall high point driver of the two-day show.This year promises a great field of cars as many of the top drivers from Kansas, Colorado, Nebraska and Oklahoma will converge on the 3/8 mile oval in Hays to compete in one of the most prestigious races on the URSS schedule.2017 URSS champion Zach Blurton leads the current point standings coming in to the weekend followed by Ty Williams, Brian Herbert, Chad Salem and Tyler Knight rounding out the top five.Races start at 7 p.m. both nights. Both nights will be broadcast on racinboys.com with Kyler Fetters calling the action live.
Dodgers southpaw Alex Wood was ripped badly when he pitched in Arizona last Friday, to the tune of eight runs — six earned — in just 1 2/3 innings.What a difference four days make.On Wednesday, Wood came through with an absolute masterpiece. He allowed just one hit over eight innings and the Dodgers rode a home run by A.J. Ellis and an RBI single by Corey Seager to a 2-0 victory over the Colorado Rockies before 45,906 at Dodger Stadium.Wood allowed just a single by Kyle Parker in the second inning. He struck out five and did not walk a batter on 78 pitches. Thirteen of his 24 outs were via the ground ball. When Wood (11-10) came into the dugout after a quick eighth, Mattingly went to shake his hand, the sign he was coming out. Wood at first refused to shake.“He looked at me kind of funny,” Mattingly said, laughing. “I just said, ‘That’s it, don’t even ask.’”Mattingly said that if the lead were 4-0, he might have left Wood in. Wood found the humor in fanning on the handshake.“I was a little surprised (to be coming out),” Wood said. “He came to shake my hand, I was pulling it back a little bit.”He understood the thinking.• Video: Dodgers manager Don Mattingly discusses pulling Alex Wood after 8 innings“Obviously, you always want to stay in, but I wasn’t going to fight too hard, especially after my last one,” he said. “If I wouldn’t have had that last one I probably would have put up more of a fight, but 2-0 ballgame, we’re trying to clinch our playoff berth and have some confidence going into this weekend against Pittsburgh.“Ninth inning, as everybody knows, is Kenley’s for the most part.”The Dodgers have Thursday off and host Pittsburgh beginning Friday.Wood liked his stuff.• Photos: Los Angeles Dodgers defeat the Colorado Rockies 2-0“Yeah, you know, baseball’s a funny game, right?” he said. “It was obviously my worst of the year the last time out. Didn’t really have all three (pitches), which doesn’t happen hardly ever.“Then come in tonight, thought we commanded the fastball to both sides of the plate and felt the changeup was real good. And, obviously, got a lot of early contact tonight.” Wood was asked how the four days between the two starts were.“Long,” he said.Ellis hit his sixth home run of the year off Rockies southpaw starter Jorge De La Rosa (9-7) in the second inning and Seager made it 2-0 with an RBI single in the sixth after a double by Austin Barnes.Ellis loved what he saw from Wood.“He was phenomenal tonight, as good as I’ve caught him,” Ellis said. “And I know for him personally coming off Arizona, this was a big start for him and a big start for us trying to win the series. Give him all the credit, he was outstanding tonight.”Seager said the 2-0 lead felt larger the way Wood was working.“Wood threw really well,” he said. “Eight innings, one hit, something like that. When you do that, one or two runs is like eight or nine runs.”The Dodgers did not start several regulars after Tuesday’s marathon and their lineup included four players who were recently in Triple-A. Third-string catcher Barnes, a former infielder, started at second base with Chase Utley starting at first for Adrian Gonzalez. The low pitch-count notwithstanding, Wood did not get the chance to finish because closer Kenley Jansen was brought in to save his 32nd game. Jansen gave up a two-out single to Charlie Blackmon before striking out Carlos Gonzalez to end the game.The game took 2 hours and eight minutes, a night after the teams played for 16 innings over 5 hours and 23 minutes.The first-place Dodgers (84-61) reduced their magic number to 10 and retained their lead of 7 1/2 games over the Giants in the NL West.Dodgers manager Don Mattingly talked about the ground balls Wood induced.“It seemed like he (Wood) was down all night,” Mattingly said. “He just seemed a little sharper with everything. You never know what goes on from game to game. It was good tonight. He got on a little roll early and just kept his pitch-count down.” Newsroom GuidelinesNews TipsContact UsReport an Error
MORE: Jarrett Stidham has a monumental task ahead of him in replacing Tom BradyNow, who will all of these quarterbacks be throwing the ball to? That choice is easily the ripped Seahawks receiver from Ole Miss.DK Metcalf: Larry the LobsterBig Larry energy over here.DK Metcalf is an NFL prospect… at WIDE RECEIVER 💪😳📸 via @BunkiePerkins pic.twitter.com/n4UGAch8fw— FanDuel (@FanDuel) February 11, 2019Bout’ to play some volleyball at the beach! pic.twitter.com/laZw6jxJ0P— Larry The Lobster (@Larry_T_Lobster) February 5, 2015 The NFL will take a surprising step to boost its popularity among children next season after reportedly agreeing to broadcast a first-round playoff game on kid-targeted Nickelodeon as well as CBS.Where “SpongeBob SquarePants” captivated viewers before, football will try to win over the hearts of youngsters around the U.S. That got us to thinking: Which “SpongeBob” characters would NFL quarterbacks be if they entered the digital realm?MORE: NFL free agency gradesHere’s our attempt to answer that question in a list that will almost certainly lead to disagreement and indignation. Just remember that we tried our best:Patrick Mahomes: SpongeBob SquarePantsMahomes is fresh off a Super Bowl title and is having one of the best starts to a career in NFL history (76 TDs in 31 games). He seems well-positioned to own the next generation of league success. The top quarterback is usually considered the protagonist of the league, and competition for the role will probably be between him and Lamar Jackson for years to come. Like SpongeBob, Mahomes’ voice is a source of great amusement, and he is generally well-liked even by opposing fans.Mitchell Trubisky: Patrick StarWatching Trubisky try to find his footing in the NFL is kind of like watching Patrick Star try to get through a door.Colt McCoy: Sandy CheeksThe former Longhorns great is as close to the sea squirrel as we can get. He lives in his backup quarterback bubble until called to action.He might not reside in the Southwest any longer, but don’t you dare insult where he came from.Philip Rivers: Squidward TentaclesThe grumpiest quarterback in the NFL really just loves his craft, just like the no-nonsense curmudgeon of Bikini Bottom.Here’s how Rivers looked every time he felt let down by Chargers teammates in recent years:Jared Goff: Eugene H. KrabsIt took Goff little time to secure a four-year, $134 million contract extension that has set him up for life pretty well despite suspect on-field production. Mr. Krabs would be so proud of the finesse.Lamar Jackson: Sheldon J. PlanktonJackson’s entire career is devoted to making everyone who has ever overlooked him or disrespected his game look like idiots. He dropped to No. 32 in the 2018 NFL Draft and was told by teams and evaluators he would be better served as a wide receiver. An MVP season shut that talk down, but the Ravens signal-caller is unlikely to ever lose his sharp edge.His motivations, then, bear similarities to those of Plankton. Plankton, of course, lives to exact revenge for the lack of attention he receives, constantly looking to upend Bikini Bottom.Unlike Plankton, however, Jackson already seems to have the secret formula and a road to massive success.Aaron Rodgers: Flying DutchmanHe’s a baaaaaad man.Here’s Rodgers in the clutch:Tom Brady: King NeptuneThere is no doubting Brady, the GOAT, rules the NFL quarterback kingdom.His throne, of course, will be in a new city for the first time next season.