Tag: 上海419论坛

9 months agoLazio coach Simone Inzaghi: We’re serious about Coppa Italia

first_imgAbout the authorCarlos VolcanoShare the loveHave your say Lazio coach Simone Inzaghi: We’re serious about Coppa Italiaby Carlos Volcano9 months agoSend to a friendShare the loveLazio coach Simone Inzaghi says he’ll select a strong line-up for their Coppa Italia tie with Novara.Lazio meet Novara today in the round of 16.”Tomorrow’s match is going to be important and there is a place in the quarter-final up for grabs,” said Inzaghi.“We have always achieved good results in the Coppa Italia and want to continue that trend in the current campaign. The lads are in good shape and returned from vacation with a lot of motivation. We’ll put in a great performance, because our objective is to keep pushing hard in this tournament.“Over the last two years, we played in the Final and the semi-final. We know Novara are going to take this seriously and I want my team to take it seriously too, as we want to do well at all costs.” last_img read more

Toys R Us files for bankruptcy protection in Canada

first_imgTORONTO – Toys “R” Us Canada has initiated bankruptcy proceedings in an Ontario court a day after it filed for creditor protection in the U.S.The company said Tuesday its 82 stores across Canada, as well as its e-commerce sites will continue to operate as usual during its restructuring process under the Companies’ Creditors Arrangement Act.“The restructuring is intended to facilitate the continued success of our iconic brands; building a stronger company for our customers, business partners and team members,” Melanie Teed-Murch, president of Toys “R” Us and Babies “R” Us Canada said in a statement.The move comes at a critical time leading into the holiday season that is crucial to retailers’ bottom lines.The company has financing commitments to ensure normal operations throughout the CCAA proceedings, including stocking the hottest toys for the holidays and honouring all gift cards, warranties and returns, Teed-Murch said.“We are confident that this process will enable us to leverage Toys “R” Us’ existing strengths to succeed.”Toys “R” Us filed Chapter 11 documents late Monday in U.S. Bankruptcy Court in Richmond, Virginia.The company said its approximately 1,600 Toys “R” Us and Babies “R” Us stores around the world – the “vast majority of which are profitable” – and its web portals continue to operate as usual.The chain also said it had secured US$3 billion in financing to stay open while it restructures its outstanding debt and establishes a sustainable capital structure to invest in long-term growth.Toys “R” Us is the latest brick-and-mortar retailer to struggle amid growing competition from online merchants and changing consumer preferences, with Sears Canada filing for CCAA protection this past June.if Toys “R” Us had offered a better online offering “perhaps they could have avoided such fate,” said Ryerson University business professor Seung Hwan Lee.“A lot of physical stores and brick-and-mortar stores are struggling with this concept because Amazon is really taking over,” said Lee, an associate professor at the Ted Rogers School of Retail Management.Meanwhile, children are increasingly gravitating towards digital toys rather than physical trinkets, he added.“There are consumer trends that are changing from both the parents’ side and the children’s side, and I don’t know if Toys “R” Us was innovative enough to adapt to that,” Lee said.This comes as Canadian retailer Mastermind Toys announced its continued expansion, with its 56th store opening in Orleans, Ont. on Tuesday. It said it plans to open four more stores across the country later this year, on top of the seven stores it had already launched in 2017.Lee says some brick-and-mortar retailers have been able to lure in customers by offering a more interactive experience in their stores.“Toys “R” Us, when you go in there, it looks exactly the same as, perhaps, 10, 20 years ago,” he said. “It’s aisles of toys, and you get to maybe try out some of the things, but there is nothing innovative about the physical store itself that draws people in.”Toys “R” Us Canada said Tuesday it is extending a “customer-centric store format that opened in Langley, British Columbia in July to a new store in Barrie, Ont. that will open in November. The format includes dedicated play areas, interactive stations for kid, mobile pay and Wi-Fi into the parking lot to make curbsite pick up easier.The company, which is headquartered in Wayne, N.J., and has nearly 65,000 employees worldwide, says it is committed to working with its vendors to ensure inventory levels are maintained and products continue to be delivered.Toys “R” Us, a major force in toy retailing in the 1980s and early 1990s, started losing shoppers to discounters like Walmart and Target and then to Amazon. GlobalData Retail estimates that in 2016 about 13.7 per cent of toy sales were made online, up from 6.5 per cent five years ago.While toy sales overall have held up fairly well, they are shifting toward discounters and online companies. U.S. toy sales rose 6 per cent last year on top of a seven per cent increase in the prior year, says NPD Group Inc., a market research firm. That was the biggest increase since 1999 and was fuelled by several blockbuster movies.—With files from the Associated Presslast_img read more

Buckeye briefs Ohio State athletes accumulate multitude of awards

Men’s Tennis falls in indoor championships The No. 3 Ohio State men’s tennis team advanced to the championship match in the ITA National Team Indoors after defeating No. 2 Virginia, 4-1, Sunday, but fell to No. 1 USC, 4-3, in the final match. The loss was the Buckeyes’ first of the season as their record drops to 12-1 overall. OSU returns home to face Kentucky for a match scheduled for Feb. 25. Baseball’s Dezse named Big Ten Player of the Week Ohio State sophomore first baseman and pitcher Josh Dezse was named the Big Ten Player of the Week for his performance in the Big Ten/Big East Challenge. Dezse went 7-for-14 overall including a home run, five RBIs and four runs. In all three games Dezse had at least two hits as OSU won two out of the three contests. Many publications named Dezse a preseason first-team All-American. This is the third time in Dezse’s career that he’s been named the conference’s player of the week. The baseball team will travel to Atlanta, Ga., for a three-game series against No. 10 Georgia Tech this weekend. Spooner in contention for player of the year honors in women’s hockey Senior forward Natalie Spooner is one of 30 final candidates for the 2012 Patty Kazmaier Memorial Award, which is given to the top player in women’s college ice hockey. Spooner helped lead the Buckeyes to a 16-14-4 regular season record while averaging 0.94 goals per game. Men’s Lacrosse upsets No. 5 Denver The Ohio State men’s lacrosse team beat Denver, 10-9, Sunday to bring their record to 3-0 on the season. Junior attackman Logan Schuss had five goals in the contest which helped him earn ECAC Lacrosse League Offensive Player of the Week honors. Schuss has had at least one point in every game of his collegiate career. He has totaled 15 points and 10 goals on the season, which brings him to 123 points in his career. That total makes him 20th in Ohio State history. Dean earns Big Ten Co-Gymnast of the Week honors Junior gymnast Colleen Dean was named Big Ten Co-Gymnast of the Week along with Nebraska freshman Jessie DeZiel Monday. Dean won first place in the all-around competition in a dual meet with Denver Saturday. The team combined for a program record 197.625 points. The team next competes at home against Penn State Saturday at 4 p.m. read more

Ohio State mens basketball holds off Illinois on road 4839

Junior center Amir Williams (23) reaches up for a shot. OSU beat Illinois, 48-39, Feb. 15 at the State Farm Center in Champaign, Ill. Courtesy of Brenton Tse / The Daily IlliniAs March approaches and college basketball teams look to build their résumés, perhaps the most important thing any team can have is a short memory.Just four days after having a three-game winning streak snapped at home by archrival No.15 Michigan, 70-60, the Ohio State Buckeyes got back to their winning ways against Illinois, beating the Fighting Illini, 48-39.Despite a tough first half where the Buckeyes trailed by as many as six points — including a three-point margin at halftime — No. 22 OSU (20-6, 7-6, fifth in the Big Ten) would manage to fight its way back in the second half.Five points from junior forward LaQuinton Ross — who finished the game with nine points — followed by a 3-pointer from senior guard Aaron Craft was enough for OSU to take a 28-25 lead with 15:14 remaining. The Buckeyes would never trail again.Although the Fighting Illini (14-12, 3-10) would cut the lead to one at 30-29 with 12:19 left, OSU would score the next 12 points and secure its 20th win of the season. It is the ninth consecutive season OSU has won at least 20 games.Despite not playing in the final 10:13 of the first half, Craft finished the game with a game-high 14 points.Freshman forward Marc Loving and sophomore guard Amedeo Della Valle would contribute for OSU off the bench, scoring eight and five points respectively.Illinois junior center Nnanna Egwu continued to hurt OSU on the glass, recording a career-high 13 rebounds on the night to go with six points.OSU’s 48 points were its lowest total of the season, but managed to hold Illinois to just 16 points in the second half. The 39 points by Illinois were the second fewest allowed by the Buckeyes this season, with only the 35 scored by Marquette Nov. 16 being less.Next up, OSU is scheduled to return to the Schottenstein Center for a matchup against Northwestern (12-13, 5-7, seventh in the Big Ten) Wednesday at 7 p.m. read more

More Zika for Grand Turk

first_imgFacebook Twitter Google+LinkedInPinterestWhatsAppGrand Turk, TCI, January 9, 2017 –  Grand Turk sees cases of Zika virus surge as the Ministry of Health gives an update on recorded cases of the mosquito borne, sexually transmitted disease.Just days into the New Year, the public learned that there are eight new cases of Zika for the TCI, bringing the national total of on record cases to 24.   Seven of those eight cases were found in Grand Turk; the Capital and the island which hosts major cruise liners and thousands of tourists per day.  It is believed the rainy season is responsible in part for the new cases from October 14 through December 7, 2016.The ‘tip of the iceberg effect’ must be ever mindful, as Zika has the uniqueness of being asymptomatic, meaning some people do not even know that they have it, therefore the true number of cases will likely never be known in any society.Go to MagneticMediaTV.com for the tips and advice from the Ministry of Health on how to be Zika free. Facebook Twitter Google+LinkedInPinterestWhatsApp Related Items:center_img #MagneticNewsMedia#MorezikeforGrandTurklast_img read more

PIC After no makeup look Shloka Mehta looks ravishing in this yellow

first_imgA few days back, a mushy and cosy picture of Akash Ambani and Shloka Mehta had started doing the rounds. The duo seemed to be engaged in a candid banter, where Shloka was clicked teasing Akash as he hid his face with his hands.As per a report in Woman’s Era, the Ambanis had decided to gift an exquisite diamond set to Shloka Mehta as a wedding present. Nita Ambani wanted to gift something quite unique and special to Shloka and thus decided on buying a beautiful set made from the most attractive diamonds. The diamond set is rumoured to be quite a niche in its design and cut.Shloka is married to Akash Ambani. The wedding which took place on March 9 at the Jio Gardens, saw the crème-de-la-crème of society in full attendance. InstagramJust a few days ago, we had spotted the Ambani bahu – Shloka Mehta – sporting a no make-up look while coming back from London after watching the India – Pakistan match. And now, a new picture of Shloka, flaunting a yellow lehenga has gone viral.Shloka, the elder daughter-in-law of the Ambani family, is quite famous for her fashion sense and style statements. While people couldn’t stop praising her no make-up, fuss-free casual sweatshirt look while coming back to the country, it is her breath-taking look in an Anamika Khanna lehenga choli that has blown us over.Anamika Khanna shared the picture of Shloka wearing her lehenga on Instagram. Designed in hues of mustard yellow and orange, the lehenga and blouse had floral motifs and a thick border. Shloka complimented the look with kohl-eyes, nude lipstick, pearl maang-tikka with flowers and a bun. Netizens have complimented not just Shloka, but her fashion sense and the beautiful lehenga too.last_img read more

We are hopeful of 125 GST rate on gold Abaran Jewellers CEO

first_imgPeople busy buying jewellery on “Akshaya Tritiya” in Nagpur, on April 28, 2017.IANSOn June 3, the Goods and Services Tax (GST) Council will finalise the tax rate on gold, among four or five items that were left uncovered in the previous GST Council meeting on May 18-19. The jewellery industry is hopeful of a lower rate on gold even as it braces up for a higher rate. In an interview with International Business Times India edition, Pratap Kamath, CEO of Abaran Jewellers and founder-member of the All India Gems and Jewellery Trade Federation (AIGJF) shares his views on the subject and the likely impact on the Rs 3 lakh crore trade. Edited excerpts:International Business Times (IBT): What would be the GST rate on gold?Pratap Kamath (PK): We have been requesting for 1.25 percent but the feeler that we are getting is that the government is looking at 4 percent.IBT: Did any delegation from AIGJF meet ministers or officials in this regard?PK: Yes, we had many meetings and we have one more scheduled…our (AIGJF) chairman Nitin Khandelwal will be meeting finance minister Arun Jaitley either on May 29 or 30. A meeting with the under-secretary in the finance ministry has also been scheduled.IBT: To make a case for 1.25 percent GST on gold?PK: Yes, that’s right.IBT: How hopeful are you?PK: We are very positive…the fact that the GST Council has kept a decision on gold pending till now is an indication…see at 1.25 percent, compliance will be high, which is what the government wants. If they fix the rate at 4 or 5 percent, compliance will be very low. As it is, the import duty on gold is very high, at 10 percent.IBT: How would gold prices trend post finalisation of GST rate?PK: I don’t think much… it would be in the range of 2 to 4 percent, up or down, depending on the rate.IBT: How do you think demand for physical gold has been impacted due to gold bond schemes?PK: It’s not significant but yes, of late, it is picking up.IBT: How do you foresee the initial days of post GST era for the trade?PK: There will be some disruption for the next few months as traders come to terms with compliance and other issues.IBT: How was the quarter (January-March 2017) gone by and the next two months?PK: Very bad for us…on an average, it was down 30 to 40 percent, YoY and even now, it has not picked up much. Demonetisation severely affected our business. There was a general sense of fear among buyers but we are hopeful that things would improve in the next few months.IBT: What’s your view on the Modi government’s performance in three years?PK: We are in a nascent stage…most decisions that have been taken are drastic…and of course, with all the good intentions. But the results will be felt only in the long term. Abaran Jewellers store in Bengaluru.YouTubelast_img read more

Setting the stage

first_imgBringing together the best of Indian theatre from the year gone by, the Mahindra Excellence in Theatre Awards and Festival (META) is staging some exceptional plays in the Capital at LTG Auditorium and Kamani Auditorium. The Festival is on till March 26.Dhou… The Wave by the nominated in the Best Director, Best Innovative Sound Design, Best Stage Design, Best Costume Design, Best Choreography, Best Actor in Supporting Role(Female), Best Ensemble category was performed on March 23. Also Read – ‘Playing Jojo was emotionally exhausting’Produced by Purbaranga and directed by Gunakar Dev Goswami,  Dhou, the wave is a powerful story of a lonely, wise old fisherman who conquers a magnificent fish, endures the heart breaking loss of it and rises gallantly above his defeat. Kaumudi, nominated in categories such as Best Director, Best Actor in a Lead Role (Male), Best Actor in a Supporting Role (Male), Best Original Script, Best Ensemble was about a rite of passage. Kaumudi has been inspired by two texts: Anand’s Malayalam novel Vyasam Vigneswaram and Jorge Luis Borges’ essay Blindness. Using the ‘moonlit timeless night’ when Krishna delivers his sermon to Arjuna as its central trope, this play explores the dynamics between an estranged father-son duo who play Eklavya’s ghost and Abhimanyu respectively, in a theatre, in late 1960’s Allahabad. The father, Satyasheel, who is a great actor and has almost lost his sight, is at his final three performances. Thus son, Paritosh, who grew up with the void of not having a father by his side, has come to challenge not only the father but also his entire school of thought. Also Read – Leslie doing new comedy special with NetflixKaumudi is hinged on three central questions: Whose life is more valuable, an older or a younger person’s? Is personal ethic more important than public ethic? Does art have an unction, and do we make art or does art make us? It also holds up a mirror to it and questions theatre: Matthi, performed on March 24 is nominated in the Best Director, Best Stage Design, Best Light Design, Best Actor in a Supporting Role (Female), Best Original Script, Best Ensemble, Best Choreography categories.  Produced by Malayalakalanilayam and directed by Jino Joseph the play travels through the Kerala during 1970 – 80s with its political, social and cultural rigor and people’s collective movements. It portrays its cultural deterioration with migrant labors and the shift in the ideology and social harmony. Another play screened on March 24 was Still and Still Moving at the Kamani Auditorium Time. Nominated for Best Director, Best Original Script, Best Actor in a lead Role (Male), Best Light Design, the play is produced by Tadpole Repertory and directed directed by Neel Chaudhari.Still and Still Moving is set in North Delhi and Gurgaon. It is the story of Partho, a reclusive writer in his forties, and Adil, a young college student. Their fractured love affair plays out across two poles of a changing metropolis, punctuated by observations on the interactions of men on the Delhi Metro.last_img read more

All govt hospitals medical colleges set to introduce online OPD booking

first_imgKolkata: All government hospitals and medical colleges in the city and the districts will soon implement online booking system for the Outpatient Departments (OPDs) to reduce the long queues which are often found inside the hospital premises.A centralised platform would soon be made functional so that patients from various parts of the state can visit the portal for booking tickets for the OPDs in any of the government hospitals and medical colleges. One of the main objectives of the initiative is to provide patients hassle-free treatment. Also Read – Bose & Gandhi: More similar than apart, says Sugata BoseIt may be mentioned that a large number of patients from various parts of the state visit various OPDs in government hospitals on a regular basis. As a result, the patients often have to stand in long queues before getting a chance to consult a doctor. The online ticket booking system has already been introduced on an experimental basis at SSKM Hospital, where people can book their tickets by logging onto the Health department’s website www.wbhealth.gov.in before visiting the hospital. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataThe state Health department is now planning to introduce a new system, where ticket booking for all OPDs of government hospitals and medical colleges can be brought under one umbrella. According to Health department sources there will be separate windows inside the ticket-booking portal, which will address the different needs of patients across the state. According to a senior Health department official, the patients will be able to book their ticket seven days prior to the date of visit. They won’t have to pay any fees for availing the online service. But in case of a patient visiting the hospital OPD for booking a ticket, he/she has to pay Rs 2 for buying a ticket. There will be separate options for different hospitals and medical colleges. The patients will get to know the details about the doctors of a department as well. They will also be able to register their preferences while booking a ticket. The patients will have to get a printed copy of the ticket once they successfully complete the process online. At the time of hospital visit, the patients will have to submit the printed copy at the designated counters of the hospital.last_img read more

Signature adds The Grand at Moon Palace Cancun

first_img Travelweek Group Share Signature adds The Grand at Moon Palace Cancun Monday, July 17, 2017 << Previous PostNext Post >>center_img TORONTO — Signature Vacations’ Crown Collection of luxury all-inclusive resorts now includes The Grand at Moon Palace Cancun, opened this past May.Value-added client benefits and perks include resort credits valued at $1,500 for golf, spa treatments, room upgrades and the like, unlimited à la carte dining and a welcoming bottle of wine in the room.Families that book by Aug. 31, 2017 also get exclusive perks including kids stay, eat and play free deals for young guests ages two to 17. This time-limited offer is valid on select departures up to and including Oct. 31, 2018. Some blackout dates apply.Signature notes that the new resort offers a solid blend of luxury, relaxation, and entertainment for all types of guests. “Families will enjoy spacious Deluxe Rooms designed to accommodate up to six guests, and younger travellers can take advantage of endless fun in the sun: from the resort’s expansive waterpark equipped with a lazy river, slides and a wave rider, to the bowling alley, to the action-packed kids and teens club.”More news:  AMResorts has a new Sr. Dir. of Cdn. Sales & Consortia Rel’nsOther amenities include the AWE Spa, seven pools and dining options including Lebanese, Peruvian, Italian, Asian, French and steakhouse restaurants.Guests staying at The Grand at Moon Palace also get free exchange privileges to the adjacent Moon Palace Golf Resort and Spa. From Dec. 22, 2017 – Jan. 3, 2018 visitors at the resort can be some of the first guests to be dazzled by Broadway’s biggest-selling magic show, The Illusionists 2.0. Guests must purchase tickets to The Illusionists 2.0 separately. Tickets can be purchased online. Tags: Palace Resorts, Signature Vacations Posted bylast_img read more

Trafalgars 20202021 Asia Program includes nine new itineraries

first_img<< Previous PostNext Post >> Tags: Asia, Trafalgar Posted by Thursday, July 25, 2019 TORONTO — Nine new trips have been unveiled as part of Trafalgar’s 2020/2021 Asia program, bringing its total offering in the region to 32 trips across nine countries.“We are so excited to be unlocking more of Asia in 2020/2021, with our nine new trips being a reflection of how much our clients love exploring Asia with Trafalgar,” said Janice Farnum, the brand’s Director of Product for Asia and Africa. “With four nights in each destination, one of my personal favourites, which I know clients will love, is our new Saigon and Bangkok Explorer. They can settle into the rhythms of these iconic cities and really feel like a local – which is what we’re all about.”New additions include the ‘Saigon and Bangkok Explorer’, which is part of the company’s ‘City Explorer’ series. Available as a nine-day standalone trip or with a three-day Phuket extension, this trip includes a ‘Be My Guest’ experience featuring a farm-to-table lunch on an organic farm outside Ho Chi Minh, and a factory visit to learn about the silk industry.More news:  Sunwing offers ultimate package deal ahead of YXU flights to SNU, PUJAlso new is ‘Colourful India – Celebrate Holi’ featuring Diwali, the Festival of Light. Guests will don traditional attire and join a local family to take part in the ‘puja’, a sacred ritual and offering to Lakshmi, the Goddess of Wealth.Trafalgar is also extending its ‘Be My guest’ series to include a brand new Japanese Kaiseki and Tea Experience, during which clients will participate in a Yamato tea drinking ceremony with a local family.Moreover, the company continues to stay true to its commitment to using travel as a force for good by including at least one ‘JoinTrafalgar’ experience on every Asia itinerary. These experiences allow clients to make a meaningful difference in the places they visit, and include a performance by a group of blind youth musicians, which supports the Ho Chi Minh Blind Centre that provides training for the visually impaired.“With the colours of Holi, our incredible ‘Be My Guests,’ our wonderful Travel Directors and experiences that ignite the senses, Trafalgar Asia 2020/2021 offers more for clients than ever before. With JoinTrafalgar initiatives on all our Asia itineraries, I’m proud we can enable clients to make a positive impact in the places we visit. It’s a travel experience you cannot get elsewhere,” added Farnum.center_img Travelweek Group Share Trafalgar’s 2020/2021 Asia Program includes nine new itinerarieslast_img read more

Former Cardinals kicker Phil Dawson retires

first_img Former Cardinals kicker Phil Dawson retires Arizona Cardinals safety Tyrann Mathieu finished the 2015 season tied for sixth in the league with five interceptions in 14 games.Mathieu played 67.5 percent of his defensive snaps at cornerback that season, and Pro Football Focus gave him the highest grade at the position.But Mathieu intercepted only one pass in 10 games in 2016 and registered 35 tackles, less than half as many compared to 2015 (89).Head coach Bruce Arians met with the media on Wednesday in London and said Mathieu has not looked like the 2015 version of himself on the field this season. “No. Healthy-wise, he is, but he’s not playing like it yet,” Arians said.PFF had Mathieu as the lowest-graded safety in football on Sept. 27, and his overall grade for the season of 47.5 is considered poor on PFF’s scale. Through six games, he has one interception, two passes defensed and 29 tackles.Mathieu’s performance combined with Justin Bethel up-and-down early season play probably explain some of why the Cardinals’ defense has given up the sixth-most passing yards (1,500) and the second most touchdowns (13).Arians said Mathieu’s performance this season probably has to do with his confidence, but the former LSU Tiger told the media on Thursday he feels good going forward.“I think confidence comes with, like I said, making splash plays, just making the plays that I’ve made since I was 5 years old, and those plays will come,” Mathieu said. “Like I said, my focus right now is playing well in critical situations.”Mathieu said he can no longer focus on splash plays because those will come with consistent performances in critical situations. The former third-round pick said that is his mindset going forward.“Yeah, I would say so,” Mathieu said. “It would have definitely taken me out of my game, but I’ve got a great group of guys around me. I think, ultimately, my teammates believe in me, and at the end of the day, that’s all that really matters.” The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Safety Tyrann Mathieu of the Arizona Cardinals, left, and Brandon Williams, right, attend an NFL training session at the London Irish rugby team training ground in the Sunbury-on-Thames, a suburb of south west London, Thursday, Oct. 19, 2017. The Arizona Cardinals are preparing for an NFL regular season game against the Los Angeles Rams in London on Sunday. (AP Photo/Kirsty Wigglesworth) Derrick Hall satisfied with D-backs’ buying and sellingcenter_img Top Stories 25 Comments   Share   Mathieu flashed in the preseason and many thought the Honey Badger was back. But other than a game-sealing interception against the Indianapolis Colts, his performances in exhibition games has yet to translate to the games that count. Grace expects Greinke trade to have emotional impactlast_img read more

Sky has bolstered its paymonthly OTT service Now

first_imgSky has bolstered its pay-monthly OTT service, Now TV, by adding ten TV channels – including Sky1, Discovery and MTV – as part of a new entertainment package.The Now TV Entertainment Month Pass will give users access to Sky 1, Sky Atlantic, Sky Living, Sky Arts 1, Discovery, MTV, Comedy Central, Gold, Disney and Fox for an introductory price of £4.99 (€5.82) per-month.UK pay TV operator Sky said that with premieres of new series of Game of Thrones, The Following and Mad Men coming up on Sky Atlantic, Now TV will be “the only place to see all the new episodes on a month-to-month, pay-as-you-go basis.”Other shows that will be accessible as part of the package include Sky 1’s Karl Pilkington: The Moaning of Life, Sky Living’s Dracula, Sky Arts 1’s A Young Doctor’s Notebook & Other Stories, Sky Atlantic’s Hello Ladies and MTV’s Geordie Shore.Additionally, the Entertainment Month Pass will give viewers access to entire box sets of shows like The Wire.“Millions of people can now go online to watch some of the best entertainment channels, including Sky 1, Sky Atlantic and Comedy Central. Now TV offers pay-as-you-go access to brand new episodes of home-grown British shows and the biggest and best US series for anyone with broadband,” said Gidon Katz, Director of Now TV.The entertainment option add to the movies and sports packages Sky already offers through Now TV, with the launch part of a planned expansion of the service.Sky recently dropped the price of its movies package, which offers Sky Movies titles and was the first content to go live on Now TV, from £15 to £8.99 per-month. Sky Sports access on the online platform is priced at £9.99 per-day.Sky launched Now TV last year as a way to tap into a new user base and compete against rising online players like Netflix and Amazon’s LoveFilm. Users are not tied into long-term contracts and can access Now TV across a range of devices.Sky said that the Now TV Entertainment Month Pass is available from today on the Now TV Box, PS3, Roku, Macs and PCs. Other supported devices will be introduced over the coming months, including iPhone, iPad, selected Android smartphones, Xbox, LG Smart TVs and selected LG media devices.last_img read more

Justins note America is in unprecedented territo

first_imgJustin’s note: America is in unprecedented territory.For starters, the average American is over $40,000 in debt… and that’s grown 15% over the past four years. Meanwhile, wages and the U.S. economy aren’t keeping up…Stansberry Research founder Porter Stansberry believes there is only one possible outcome: a “Debt Jubilee.”That’s why today, we’re sharing the first chapter of Porter’s book The American Jubilee. In it, he reveals the four conditions that would bring about a debt jubilee, and shows just how close we are to one taking place…By Porter Stansberry, founder, Stansberry ResearchIf you study American history, you’ll see that Debt Jubilees occur only in a unique type of extreme political environment.After all, a Jubilee is a radical measure.The government essentially steals money from one group and hands it to another.In order for this to occur, four elements must be in place… Sounds familiar, doesn’t it?We have the largest gap ever between the rich and poor…We have huge increases in violent protests about immigration and race…We have a completely ineffective government…And we have extreme animosity toward the “elites” from both the left and right.Check… check… check… and check.There’s actually a name for this type of political and social phenomenon.It’s called “populism.” And it emerges every 30 to 40 years. There must be cultural threats from those with different values or from outsiders (in other words, minority populations and immigrants). During the 1930s, just like today, the wealthy acquired a much higher-than-normal percentage of our nation’s wealth…And in both the 1930s and today, the percentage of the population who were foreign-born was higher than normal… causing animosity among the “common man.”Just like today, the economic conditions of the 1930s caused extreme income inequality.Back then, the top 10% earned 45% of all income (compared with 50% today) and owned 85% of the wealth (compared with 75% today).Even the political characters are the same…The 1930s saw a popular socialist presidential candidate just like we had in 2016. Huey Long was a former governor of Louisiana and a U.S. senator. He proposed an income cap at $1 million… a 30-hour federal work week… and 100% income taxes at the highest level.Long even established 27,000 “Share Our Wealth” clubs around the country and had a radio show that was listened to by one in five Americans.So where did this all lead?It led to America’s most dramatic Debt Jubilee to date…Regards,Porter Stansberry Founder, Stansberry ResearchJustin’s note: According to Porter, a financial revolution is already starting to take place across America. Many aren’t aware of it. But the Charlottesville riots… the burning of inner cities… the resurgence of neo-Nazi groups… and the “Black Lives Matter” protests are all signs that a Jubilee is imminent.But you still have time to protect yourself. Porter and his team of analysts have put together a presentation to explain everything. You’ll learn how the Jubilee will play out, as well as the steps you can take to survive… and prosper… once it hits. Watch it here.In Case You Missed It…On April 26, 2018, Casey Research is hosting a pivotal event… the Pot Stock Millionaire Summit.At this summit, Doug Casey, along with Crisis Investing editor Nick Giambruno, will discuss five frontier marijuana stocks set to soar as legalization gets underway. These stocks are the best ways to get in on what Forbes calls “the best ground-floor opportunity we’ve seen since the early days of the internet.” Sign up right here. Populist movements are characterized by extreme anger at the government, at the wealthy, at the establishments, and at “newcomers” and minorities.As the director of an Alabama group that tracks violence and hate crimes around the country told Newsweek in June 2017: “There has been a massive explosion of violence across the country.”I’m sure you’ve seen this yourself.The hatred and anger is like nothing I’ve witnessed in my lifetime. And it’s coming from all sides. A member of my staff went to a book reading in Baltimore by one of the most famous left-wing authors in the country.The author told the crowd that he wished he could go back in time and smother Donald Trump in his crib as a baby… or convince Trump’s mother to have an abortion.This epitomizes the political and social environment in America today.From the protests and marches… to the refusals to stand during the national anthem…From Black Lives Matter to the anti-immigration movements… to the rejuvenation of white supremacists… to the tripling of membership in the Democratic Socialists of America.It’s clear we are in the middle of an extreme “populist” period in America.Ray Dalio, one of the richest men in America, studied the political environments of the past 100 years and concluded in March 2017…The last time that it [populism] existed as a major force in the world was in the 1930s, when most countries became populist. Over the last year, it has again emerged as a major force.Look at this chart. The big spikes show when populist politicians got the most votes in America and abroad…So, what does this all mean?It proves that what we’re experiencing today is eerily similar to what happened in the 1930s… right before the biggest and most radical Debt Jubilee in American history. The economic comparison is stunning.Interest rates hit zero leading up to each of these periods…The government went into mega money-printing mode during both periods…Printing money caused the stock market and other risky assets to boom during both periods… boosting the wealth of the rich, but doing nothing for the poor… — How I almost lost $1,000,000 in 8 hours In 8 hours, I almost lost my entire $1,000,000 life savings. But by using this “secret key” technique… I saved all my money… generated a fortune… and got to retire at 42, with more security than I’d ever imagined. I’ve been quietly using it for the past 26 years to make millions. Click here and see my “secret key” in action. Recommended Link Recommended Link Why the SECOND crypto megaboom will be bigger, starting on April 30 The Bitcoin bull market will go down in history – but DON’T WORRY if you didn’t get rich. Because the second megaboom will be MUCH BIGGER. In fact, it will DWARF anything we’ve seen, minting a whole new class of crypto millionaires. Will you join them? — The government must be ineffective at providing solutions. And there must be growing anger toward the “elites.” The wealth gap must be getting dramatically bigger.last_img read more

Click here for the full details

first_imgClick here for the full details Now, Jason says his system can flag this type of trading activity because it quickly catches what institutional buyers are doing. That type of speed is key.Here’s what he told me:Most ordinary investors miss these opportunities because they don’t know what professional investors like hedge funds and institutions are doing. But to be fair, these big-money firms work hard to keep their activity quiet – because until they’re done, it doesn’t help them if people know what they’re buying. That’s why speed is key.In his most recent Palm Beach Trader issue, Jason identified a small tech company that institutions are snapping up quickly. And his system is showing there’s likely more demand from hedge funds – which could lead to triple-digit gains in just a few months. (Subscribers can read the issue right here.)If you’re not a Palm Beach Trader subscriber, the best one-click way to get exposure to the sector is through the iShares PHLX Semiconductor ETF (SOXX). This fund holds large semiconductor companies like Nvidia, Intel, and Broadcom.Regards,Nick Rokke Analyst, The Palm Beach DailyP.S. As I mentioned above, Cantor Fitzgerald stunned everyone with its new high-speed trading system in 2012. Time magazine… The New York Times… The Telegraph… and even 60 Minutes reported on this system – which could “look up to 30 milliseconds into the future.”It was hands down the fastest high-speed trading system in Wall Street history. But now, after seven years, Jason is ready to make history again.On April 24, Jason is unveiling his own breakthrough system, which he says can spot the market’s fastest-growing stocks up to 30 days in advance – and you’re invited.As an attendee, you’ll have the chance to claim his No. 1 recommendation. And the profit potential could be enormous – as much as $9,385 in one trading day. Plus, Jason’s giving away a special three-part masterclass for free when you register now.Reader MailbagDo you plan on attending Jason’s VIP event? If you’d like to ask questions ahead of time, send them to us at feedback@caseyresearch.com. Recommended Link Seeing the Future… Before Everyone ElseIn February 2019, Jason told me his proprietary system (more on it in a moment) was seeing a rush back into semiconductor stocks – and that it was a positive sign of economic growth.Here’s what he said then:Perhaps the biggest evidence of a rush back to growth is being seen again in semiconductors. Semis got smoked last year and were essentially a toxic wasteland… And we noticed a major repricing of semis earlier this month with some stellar earnings and heavy institutional accumulation.As usual, Jason nailed that call…The sector has shot up nearly 30% in this year’s first quarter – its best start ever. And the overall market has followed.But if you think you’ve missed the boat on semiconductors, think again. Jason says his system is continuing to signal institutional buying in the sector. And that means more gains ahead for investors in these companies…Big Money Is Piling InRegular Palm Beach Daily readers know that we call Jason our Wall Street insider because he spent nearly two decades as a trader (including being a partner at Cantor Fitzgerald).But few people know this: In 2012, his firm helped create Tradeworx.The name might not ring a bell. But if you’ve read about high-speed trading in The Wall Street Journal or The New York Times – or watched the 60 Minutes special on it – you actually do know about Tradeworx.It was the fastest high-speed trading system on Wall Street – making trades in less than a second. But here’s the thing…After Jason left Cantor Fitzgerald, he created his own breakthrough system – one that can spot the biggest (and most lucrative) trades on Wall Street… up to a month in advance.That same system flagged institutional buying in semiconductors earlier this year. And it’s proven to be highly accurate on a number of other occasions, too. (For example, it predicted the sell-off in February 2018 and the rally we saw at the start of this year.) Justin’s note: Today, we’re doing something a little different from our usual fare. Our friends over at Palm Beach Research Group have an interesting story to share about a reversal in a little-known – but very important – sector of the market.Nick Rokke and Palm Beach Trader editor Jason Bodner explain why this reversal is bullish for stocks… indicates market health… and presents a huge money-making opportunity for investors.Read on to see what it is and what we can buy to profit today…By Nick Rokke, analyst, The Palm Beach Daily Toward the end of last year, semiconductor stocks tanked…Now, semiconductors are the microchips that make electronic devices work. (They’re also called the “brains” of machines.) From toasters and smartphones… to computers and complex networking equipment… the modern world couldn’t operate without them.And because the companies making them are the first part of the supply chain, they’re often the first to feel the pain when the economy slows down.In fact, as you can see in the chart below, the sector is so important that it’s widely considered a leading indicator of market health:In the second half of 2018, semiconductor companies crashed 24%. An overall 19% market meltdown soon followed.The carnage was so bad, Palm Beach Research Group’s Wall Street insider Jason Bodner called semis a “toxic wasteland.”But today, we’re seeing a reversal in this important sector. That’s bullish for stocks – and it presents a money-making opportunity for investors… Recommended Link Register here to reserve your spot President Trump’s $2.6 Trillion Revenge Against The Fed… (And How It Could Turn $250 Into An Absolute Fortune)President Trump has called the Fed “crazy”, “out of control,” and “loco”… Because despite keeping rates near zero the entire time Obama was in office… and inflation being within just .1% of their target… Under President Trump, the Fed hiked rates not once, not twice… But six times. And with it, ushered in the worst December for investors since the Great Depression. Now, President Trump will have his revenge… And, in doing so, he will give you the chance to turn $250 into an absolute fortune. — — No matter your age or expertise, if you have a computer or cellphone you can potentially profit from thisJason Bodner has cracked the code. He spent 18 years on Wall Street, was named partner at the global financial services firm Cantor Fitzgerald, and became one of the biggest power players on Wall Street. Now he’s sharing his secrets. On Wednesday, April 24 at 8 pm ET, Jason will unveil his powerful new system that helps him spot America’s fastest-growing stocks up to 30 days in advance. No matter your age, net worth, or expertise… if you have a computer or cellphone… he can show you that you can profit from this strategy with less than 20 minutes of “work” a month. Learn from a true Wall Street legend — for free.last_img read more

For the eightandahalf years she spent in prison

first_imgFor the eight-and-a-half years she spent in prison, Kristan Kerr looked forward to one thing every month: a visit from her daughter, Chloe. Visit by visit, she watched Chloe grow from a toddler into a young adult.”I just watched her grow all the way up,” Kerr says. “One visit, she couldn’t read, and then the next visit she was reading something to me.”Convicted for aggravated robbery in 2011 – she was the driver — Kerr says she wasn’t making good choices back then, and it meant missing out on a lot.She and Chloe would talk on the phone and send letters and visit, but she says you can’t do the physical, nurturing part of parenting from prison. Even though Kerr trusted that Chloe was being cared for by her grandmother, she says you never stop worrying about your kid.There are more than 225,000 women behind bars, according to the most recent 2017 federal statistics. Half are in state and federal prisons, the other half in local jails. It’s actually a slight decrease, coming after years of ballooning incarceration among women.From 1980 to 2016, the country saw a 700% increase in the number of women behind bars. Exactly how many are mothers isn’t well tracked, but a survey of women in Texas prisons showed more than 80% of them are moms.Lawmakers across the country are now considering ways to send fewer moms with minor children to jail and prison, and to help preserve parent-child bonds when they’re locked up.In Texas, lawmakers are considering bills that would promote diversion programs, probation or other community-based sentences over jail or prison time to avoid breaking up families. Tennessee recently passed legislation to do that.There were some tough times for Chloe, who’s now 12. It was hard seeing other kids with their moms, but she says it’s been good since her mother was released in October. Not that it’s been easy, exactly.”It’s been a little bit challenging because I’ve still got to get used to her, I’ve got to learn her, get comfortable with her,” Chloe says. But, she adds, “I’m happier now that she’s here, that I get to see her every day.””Many of the women, once they get arrested, are scrambling to find someone to take care of their kids,” says Michele Deitch, who studies prison issues at the University of Texas at Austin. “So a lot of kids get shuttled from place to place, and if they’re not able to find a place for them, then many of the kids end up in foster care.”Other states are looking at incarcerating parents closer to their children, and expanding visitation so kids can see mom or dad more often. Incarcerated parents who have stronger relationships with their kids, Deitch says, behave better while inside, and are less likely to commit future crimes after they’re released.”It’s really critical for the parent to not lose touch with their child, and to stay involved and to feel like they can make a difference in the child’s life to be aware of what’s happening to them,” Deitch says.Growing up with their incarcerated parents can be damaging to their children. That’s part of the reason children with incarcerated parents are more likely to end up in the criminal justice system themselves, according to Dallas lawyer Brittany Barnett. She launched Girls Embracing Mothers, a nonprofit aimed at improving outcomes for girls and their incarcerated mothers, after her own mother was sent to prison.”Even though I was a young adult when my mom went to prison, my sister and I were devastated by her incarceration,” Barnett says. “It not only impacts the person in prison, but the children are the hidden victims of their parents’ crimes.”Kristan and Chloe Kerr took part in the Girls Embracing Mothers program. Barnett says she’s optimistic about reform legislation, but hopes it’s just a first step toward a more effective and less punitive justice system.”These women aren’t bad women, they made bad choices,” Barnett says.Texas Rep. James White, a Republican, says the crimes women commit are often different from their male peers. He heads the House Committee on Corrections, and introduced a bill to address issues faced by women in prison, including pregnancy and childbirth.”I hear a lot of offenses that are linked to domestic violence, so they may stab their spouse that’s abusing them and their kids,” White says, “young women that have experienced repeated sexual abuse from a family member, women who have fallen into the trap of addiction.”Researchers agree that a history of trauma underlies a lot of the criminal behavior that lands women in jails and prisons. Kristan Kerr says many of the moms in prison with her struggled with psychological and behavioral issues.”Women, they love their kids,” she says. “Maybe they’re stuck with addiction but that’s a sickness, but that doesn’t mean they don’t want their children.”Since she’s been out, Kerr has been working through a list of goals she set for herself to rebuild her life. She’s got a job, got her driver’s license, and she’s spending lots of time with her daughter. Copyright 2019 KERA. To see more, visit KERA.last_img read more

Marijuana Workers Now Outnumber Bakers and Other Common Careers

first_img Next Article Add to Queue –shares For an industry still in its early stages, legal marijuana already has surpassed many other businesses in generating jobs.In a new report called the Marijuana Business Factbook 2017, the marijuana industry is reported to have created 165,000 to 230,000 full- and part-time jobs in the United States. According to the report, that means there are more people working in the marijuana industry than there are bakers, dental hygienists and massage therapists.The job numbers include those working at cannabis retail stores, growing facilities, marijuana-infused product companies, testing labs and ancillary businesses such as transportation and security. The numbers represent “marijuana’s rapid transformation out of the black market and into a viable economic force,” according to the report.Related: Sorry, But No You Can’t Smoke Marijuana on the Las Vegas Strip Yet.Practical mattersThe numbers also underscore one of the two practical considerations for political leaders that go beyond the decades-old “war against drugs” debate that continues at the federal level.The first is that legalized marijuana generates huge amounts of tax income for state and local governments. For example, Oregon expects to reap $200 million in adult-use marijuana taxes by 2019, and that money will go to schools, roads and law enforcement.The tax dollars generated by Colorado and other western states have politicians in other cash-starved states, such as Illinois, hoping to legalize marijuana to help balance governmental budgets.The second, which the report focused on, is job creation. Nationwide, the numbers are expected to skyrocket as California, Massachusetts and Nevada allow adult-use sales and another big state, Florida, moves forward with a regulated medical marijuana industry.Though all the new legal marijuana markets will take time to fully develop, “they have the potential to create tens of thousands of new jobs in the marijuana industry,” according to the report.Putting it in perspectiveMarijuana also has been a boon to small businesses. The majority of the jobs in marijuana are concentrated on smaller operations that only need a handful of employees.Part of the reason for this is the fact marijuana remains an illegal drug at the federal level. Because legalization has happened in a state-by-state manner, large marijuana companies employing hundreds of workers have not materialized.Related: NBA Champion John Salley Talks About the ‘Seed to Sale’ Process for Cannabis BusinessBut the jobs continue to multiply. Assuming that most marijuana industry workers do not require a college degree, here are some other, similar occupations that the marijuana industry has either surpassed or approached in the number of workers:Short-order cooks (181,600)Electronics Installers and Repairers (136,100)Library Assistants (210,700)Boilermakers (17,400)Sheet metal workers (141,000)Again, the employment numbers will only grow as legal marijuana operations go into effect in new states. Moving forward on the debate about marijuana, expect politicians to start referencing the economic benefits of cannabis over long-held objections. They may find the economic bottom line on the marijuana industry is too strong to ignore. Easy Search. Quality Finds. Your partner and digital portal for the cannabis community. Free Green Entrepreneur App dispensaries.com Guest Writer Marijuana Workers Now Outnumber Bakers and Other Common Careers July 11, 2017 Image credit: David McNew | Getty Images 3 min read Opinions expressed by Entrepreneur contributors are their own. How much has legalizing marijuana helped create jobs? Just look at the numbers. Marijuana Keep up with the latest trends and news in the cannabis industry with our free articles and videos, plus subscribe to the digital edition of Green Entrepreneur magazine. Download Our Free Android Applast_img read more

Apple Says It Does Not Want to be an Elitist Company as

first_imgApple Apple COO Jeff Williams also said analysts ‘don’t really understand the cost of what we do.’ Apple Says It Does Not Want to be an ‘Elitist’ Company as iPhone Prices Continue to Rise Next Article Apple’s COO Jeff Williams told students in North Carolina on Friday that Apple does not want to be an “elitist” company.As reported by Apple Insider, Williams gave a short speech at Elon University followed by a Q&A session. A student asked Williams about Apple’s plans to lower iPhone prices, citing a recent report which claimed the iPhone costs significantly less to manufacture than its sale price.”The stories that come out about the cost of our products [have been] the bane of my existence from the beginning of time, including our early days,” said Williams. “Analysts don’t really understand the cost of what we do and how much care we put into making our products.”Williams said he’s cognizant of the iPhone’s climbing price point,which means it has fallen behind in key markets where consumers have less disposable income. In India for example, Apple commands just 3% of market share.”We do not want to be an elitist company. That’s not — we want to be an egalitarian company, and we’ve got a lot of work going on in developing markets,” Williams said.His comments come after Apple has continued to raise the price of iPhones. The average selling price of the phones has increased by nearly 27% to $793 since 2010, helped in no small part by the $1,000 iPhone X. February 25, 2019 Add to Queue Apply Now » 2 min readcenter_img –shares The only list that measures privately-held company performance across multiple dimensions—not just revenue. This story originally appeared on Business Insider 2019 Entrepreneur 360 List Isobel Asher Hamilton Apple COO Jeff Williams Image credit: AP Photo/Marcio Jose Sanchez via BIlast_img read more

Polygenic screening could inform breast cancer risk in female survivors of pediatric

first_img Source:http://www.aacr.org/ Reviewed by James Ives, M.Psych. (Editor)Oct 26 2018Bottom Line: A combined evaluation of common variants with small effects and rare predisposing mutations among young female childhood cancer survivors may further stratify this high-risk population for subsequent breast cancer risk.Journal in Which the Study was Published: Clinical Cancer Research, a journal of the American Association for Cancer ResearchAuthor: Zhaoming Wang, PhD, associate member in the Department of Epidemiology and Cancer Control at the St. Jude Children’s Research Hospital in MemphisBackground: Female childhood cancer survivors have an increased risk of developing subsequent breast cancer compared with the general population. This increased risk has largely been attributed to cancer treatment regimens, such as chest irradiation and/or exposure to high-dose chemotherapeutic agents. Current screening of this population relies on treatments and doses used to treat childhood cancer, Wang explained.Wang previously found that survivors of childhood cancer have an increased risk of subsequent breast cancer if the survivors carry pathogenic or likely pathogenic (P/LP) mutations, such as mutations to the BRCA1 gene. “Our current study attempts to investigate the contributions to the risk of subsequent breast cancer by considering the full picture of breast cancer genetic susceptibility, which includes common genetic variants with small effects (polygenic determinants) in addition to P/LP mutations (monogenic determinants),” said Wang.How the Study Was Conducted: Wang and colleagues utilized information from the St. Jude Lifetime Cohort Study (SJLIFE) by analyzing whole-genome sequencing data for 1,133 female cancer survivors of European ancestry. Of these survivors, 47 developed one or more subsequent breast cancers.The researchers constructed a polygenic risk score (PRS) for individual survivors by calculating the weighted sum of 170 common breast cancer risk alleles present in each survivor’s genome. The researchers also evaluated the presence of P/LP mutations in 11 breast cancer predisposition genes. Relative rates of subsequent breast cancer incidence were estimated.Results: Following multivariable analysis, the researchers found that survivors in the highest PRS quintile had 2.7 times the risk of subsequent breast cancer compared to survivors in the lowest quintile. Survivors treated with chest irradiation had even higher risk; those in the highest PRS quintile treated with radiation had three times the risk of subsequent cancer compared to those in lowest quintile treated with radiation.Related StoriesCancer killing capability of lesser-known immune cells identifiedHow cell-free DNA can be targeted to prevent spread of tumorsHealthy lifestyle lowers dementia risk despite genetic predispositionSurvivors who carried P/LP mutations had 21.8 times increased risk for subsequent breast cancer compared with those who didn’t have P/LP mutations. Survivors treated with chest irradiation and who carried P/LP mutations had 10.3 times increased risk for subsequent breast cancer compared with those who didn’t have P/LP mutations treated with chest irradiation.”The PRS can identify individuals with high breast cancer risk that do not carry known pathogenic mutations,” Wang said. “Our results indicate that both polygenic determinants and large-effect rare mutations (monogenic determinants) contribute to the risk of subsequent breast cancer independently.”Notably, PRS was significantly associated with risk of subsequent breast cancer only in women less than 45 years old.”Our data supports the hypothesis that genetic risk factors play a more important role in the development of subsequent breast cancers in younger women,” Wang said. “However, this observed age-specific association could be partly due to the smaller sample size of older survivors in our study.”P/LP mutations were defined as mutations to the following breast cancer predisposition genes: BRCA1, BRCA2, TP53, PTEN, CDH1, STK11, NF1, PALB2, ATM, CHEK2, and NBN.Author’s Comments: “Our findings suggest that polygenic screening can inform personalized breast cancer surveillance in female childhood cancer survivors,” said Wang. “This method can be utilized in the clinical setting to enhance the identification of high-risk survivors to enable the early detection and potential prevention of subsequent breast cancer.”Wang also said, “Our results indicate that personalized breast cancer surveillance strategies for survivors should incorporate prior exposure to specific anti-cancer treatments, the presence of P/LP mutations, and the cumulative presence of small-effect common variants, as represented by a polygenic risk score.”Study Limitations: Limitations of the study include a relatively young cohort of childhood cancer survivors. Additionally, analysis was restricted to survivors of European ancestry; follow-up studies should be conducted within other non-European ethnic groups.last_img read more

Wave of worries takes shine off Paris Motor Show

first_img‘Frozen’Such marketing costs have also become harder to justify as carmakers invest billions in autonomous driving and electric motors, even as the outlook for sales darkens.Dudenhoffer is expecting global sales to fall 1.4 percent next year, with declines of 4 percent in the US and China.But the more immediate worry for European manufacturers is Brexit and the possibility of new duties between Britain and the continent.”Today we’re in a situation where everybody’s frozen, we’re all waiting to see what’s going to happen,” said Carlos Ghosn, head of the Renault-Nissan-Mitsubishi alliance.”I don’t think that there’s any carmaker who’s not prepared for the worst. We don’t like it but we’re prepared,” he added. © 2018 AFP From Brexit and transatlantic trade tensions to the challenges posed by China and electric vehicles, executives see plenty of reasons to worry.”Making forecasts is becoming more and more difficult,” BMW’s chief Harald Kruger told journalists. “Profitability is obviously under pressure.”It was enough to keep plenty of key players at home: Ford, Fiat-Chrysler, Nissan, VW and Mazda were among the notable absences at this year’s show.Faced with the reluctance of some industry giants to spend millions of euros on marketing, organisers responded by cutting back the show’s length to 11 days from 16.And in a bid to attract crowds who can just as easily compare models on the internet, they set up test tracks where visitors can take electric scooters and bikes for a spin.The show also teamed up with CES Las Vegas, the huge consumer electronics fair, to host dozens of tech start-ups eager to turn cars into the internet-connected “mobility solutions” of tomorrow.But some analysts say such changes aren’t enough, citing a similar absence of major carmakers at the industry’s other top shows in Detroit, Geneva or Frankfurt in recent years.”The concept needs to be redone from scratch—up to now these shows were just for putting cars next to young girls,” said Ferdinand Dudenhoffer of Germany’s Centre for Automotive Research. Renault’s aiming the K-ZE at the Chinese market Cutting-edge concept cars and promises of self-driving “lounges” painted the picture of a bright future as the Paris Motor Show got under way Tuesday, but that’s not the message being sent by industry chiefs. BMW’s Kruger said Brexit’s effects were already being felt. “The market is shrinking, and we’re selling fewer cars,” he said, adding that he too was bracing for a “difficult situation”.Yet executives still hope a last-minute breakthrough will avoid a “hard Brexit”, similar to the deal reached over a revised Nafta following US President Donald Trump’s threat to scrap the trade pact.”Frankly, we’re very happy that we have an agreement. I can tell you that no agreement would have been much more devastating for the development of our operations in North America,” Ghosn said. Carmakers brace for shocks as electrified future looms Brexit is putting the brakes on the car industry’s outlook Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. The stuff of dreams on display at the Paris show Citation: Wave of worries takes shine off Paris Motor Show (2018, October 2) retrieved 17 July 2019 from https://phys.org/news/2018-10-paris-motor.html ‘Stress tests’The threats haven’t stopped carmakers from investing: BMW “will spend more money than ever, seven billion euros ($8.1 billion) on research and development this year,” mainly on electric and digital technologies, Kruger said.Both BMW and its German rival Daimler have trimmed profit forecasts for this year, not least because of charges associated with the “dieselgate” emissions cheating scandal.Strict EU limits on CO2 emissions from 2020 have contributed to plunging diesel sales, as has the prospect that many cities could start banning their use to combat smog.That has accelerated the shift to electric, along with the prospect of supplying the huge Chinese market, where officials are strongly encouraging the use of zero-emission vehicles.Renault announced this week a low-cost SUV, the K-ZE, specifically for the Chinese market.But in developed markets electric cars are still a loss-making proposition.”The amount of technology onboard is going to get bigger and bigger, and the costs higher and higher,” said PSA Group chief Carlos Tavares.He suggested that developing car-sharing systems could be a way of making them more accessible.For Maxime Lemerle, an auto specialist at the risk insurance group Euler Hermes, the wave of challenges has carmakers facing “stress tests” like those applied to banks after the 2008 financial crisis.”The question is whether they will be able to adapt to the deep changes in the automotive world,” he said.last_img read more