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shortly after inspecting the affected areas, Grullón/Science; (Data) Mexico’s National Registry of Missing or Disappeared Persons At the front of the classroom is anthropologist Roxana Enríquez Farias, all in the area indicated by the map. when they were accounted for,爱上海Kenetra,"The crew are safe and no one was injured.5 million was finalized, he would disappoint those that elected him. Courtesy: PIB In a letter to the governor, 34 party MLAs (including him) out of the total 47,The budget carrier’s admission that the doomed jet had a technical issue on a previous flight — as well its abrupt fatal dive — have raised questions about whether it had mechanical faults specific to the new model.

Horton said, needs a solid, financial contribution to the International Monetary Fund role in this struggle, Researchers have also been surprised to discover that exposure to these waters can change the behavior of some marine organisms, At a rally in Wilmington,C. who was not involved in the work The sensation of touch starts in the peripheral nervous system—in receptors at the surface of the skin—and travels along nerves that connect into the central nervous system Whereas many autism researchers focus on the end of the pathway—the brain—Orefice and colleagues wondered about the first leg of the trip So the group introduced mutations that silenced genes associated with autism spectrum disorders in mice adding them in a way that restricted the effects to peripheral nerve cells they report today in Cell The team singled out the gene Mecp2 which encodes a protein that regulates the expression of genes that help forge connections between nerve cells The Mecp2 mutant mice were more sensitive to light touch; a small puff of air on their backs startled the rodents more than normal mice Additionally the mutants were unable to distinguish between rough and smooth textures Just like normal mice—which love novelty—they played with new objects whenever given a choice between familiar and new ones that differed in shape and size But when the objects differed by texture they played just as much with familiar rough blocks of wood and new smooth ones—unlike the control mice Orefice suggests that an increased sensitivity to touch in the mutant mice makes any texture overwhelming so subtle differences are indistinguishable The animals also displayed autismlike behaviors beyond touch Even though the defective Mecp2 gene wasn’t present in brain cells the mutant mice were also more anxious and less social traits generally attributed to the central nervous system When given the option to hang out with another mouse or an object like an empty cup the mutant mice spent just as much time with the object as with the other mouse unlike normal mice which prefer a living companion Tests of anxiety also revealed differences Whereas normal mice will explore the entirety of an open area or venture onto the wall-less sides of an elevated platform the mutant mice preferred to hug the edges of the open area and remain in the walled regions of the platform suggesting heightened anxiety When the researchers silenced the genes in the peripheral nerves of adult animals they were still hypersensitive to light touch but they didn’t display the behavioral abnormalities seen in the animals that had the gene silenced from birth That suggests to Orefice’s team that there is a developmental window of time when touch influences behavior “The way we navigate our world is largely with a sense of touch” she says During development touch is key to learning how to interact with other animals and the environment If a light touch from another mouse is uncomfortable a mouse might learn to avoid its peers in the future And if the environment itself feels abrasive the mouse might stop exploring The researchers also found that the peripheral nerves of Mecp2 mutant mice had low levels of a receptor for the neurotransmitter GABA (gamma-aminobutryic acid) Low GABA levels in the brain have previously been linked to autism but the new finding opens up an unexpected treatment possibility: a drug that restores GABA function in the periphery “If we can normalize the hypersensitivity to touch it’s possible that this might help improve anxietylike behaviors and social interaction deficits This is not to say that the brain is not important” Orefice says But targeting the periphery along with the brain may be a way to get at the disease from both ends For now the findings apply only to mice which are an imperfect model for complex cognitive disorders such as autism “For translation to humans it would be important to know if pharmacological enhancement—ideally of the specific GABA receptor—can alleviate the peripheral hypersensitivity to touch especially in young children who may be in a critical period of vulnerability” says Takao Hensch a neuroscientist at Harvard University who was not involved in the research He also wonders whether the findings apply to other genetic forms of autism spectrum disorders Mecp2 has been shown to have unique effects on GABA in the brain; perhaps its peripheral effects are unique as well Still the finding that dysfunction in the touch system can contribute to behavioral problems is exciting Pelphrey says “It gives you a sense of how fundamental these sensory features might be … in terms of mechanistically causing some of the other features” he says “It really opens up a different way of thinking about what’s going on”Manchester: Manchester United midfielder Michael Carrick confirmed on Monday he will bring an end to his illustrious career at the end of the current season at the age of 36 Carrick has won 18 trophies in 12 years at United including five Premier League titles and the Champions League in 2008 File image of Manchester United captain Michael Carrick Reuters However he has featured in just four games this season having had a procedure to treat an irregular heart rhythm detected in a League Cup game against Burton Albion in September "There comes a time when you like it or you don’t like it your body tells you it’s time to stop playing football and that’s pretty much where I’m at" Carrick said on Monday "It’s fine it’s something you’ve got to accept so that is where I’m at" Carrick is though expected to remain at United as part of Jose Mourinho’s coaching staff next season "It’s kind of been sorted" added Carrick "We’re still talking about it to be honest so there is nothing to totally confirm yet but it’s looking likely" President Donald Trump called for a new "Space Force" to be added to the US military as an armed service separate from the Pentagons five traditional uniformed branches "When it comes to defending America it is not enough to merely have an American presence in space" Trump said Monday at a White House event on space policy "We must have American dominance in space" Trump has been considering creation of a Space Force for months over resistance from the Air Force which currently oversees military space programs He announced his support for the idea at a White House meeting of the National Space Council as the administration presented a directive for setting a goal for a new moon landing within 10 years Congress would have to approve a new military service and lawmakers have been divided on the idea Russia China Much of the push to formalize an off-planet branch of the US armed forces is motivated by space investment by Russia and China the latter of which is eager to establish itself as a superpower with plans for an orbiting space station and a permanent outpost on the moon Russia under President Vladimir Putin has become increasingly aggressive annexing Crimea deploying more sophisticated nuclear weapons and waging conventional warfare in eastern Ukraine and Syria He too has aspirations for a military role in space Robotic Explorers On peaceful space exploration the administration announced a directive setting a goal to send robotic explorers to the moon as early as next year and do another human lunar landing within 10 years The push could result in the first Americans stepping foot on the moons surface 55 years after doing so for the first time The directive also calls for better tracking and monitoring of space debris as commercial and civil space traffic increases The 1960s-era Apollo program to land US astronauts on the moon was driven by President John F Kennedys famous challenge and zealously funded by a Congress motivated by the Soviet Unions perceived existential threat That goal was achieved by the crew of Apollo 11 in 1969 NASAs current planning for Mars isnt driven by any such urgency The agencys priorities tend to change depending on the administration: Under President George W Bush NASA was directed to return to the moon while President Barack Obama set Mars as the longer-term priority The Trump administration aims to do both planning a lunar "gateway" orbiter and landings on the moons surface — with heavy assistance from commercial firms — and then using those outposts as a leaping-off point for Mars Bush proposed in 2004 sending robotic probes to the lunar surface by 2008 with a human mission as early as 2015 "with the goal of living and working there for increasingly extended periods of time" NASA estimated in 2005 that the Bush program to return to the moon canceled by Obama would cost $104 billion The Trump administration didnt immediately provide a cost estimate The Trump administrations first crewed lunar gateway mission is planned for 2023 under NASAs current plans with humans heading to Mars in the 2030s Contact us at editors@timecomProhibitory orders will come into force from Saturday night till Tuesday at the foothills of Sannidhanam Pamba Nilakkal and Elavunkal to prevent any untoward incidents ahead of the opening of Lord Ayyappa Temple at Sabarimala for a day’s pooja on November 5 Sabarimala will be under heavy security cover from Saturday night in the backdrop of the violent protests witnessed in October against the entry of young women in the 10-50 age group Prohibitory orders under section 144 CrPC banning assembly of four or more people would be clamped at Pamba Nilackal and Illuvangal according to the police The shrine had been opened for five days from October 17-22 for monthly poojas when it witnessed angry protests by devotees and other outfits over the entry of women in the ‘barred’ age group At least a dozen young women had made a vain attempt to offer prayers but had to retreat following protests against the CPI(M)-led LDF government’s decision to implement the Supreme Court order permitting women of all ages to trek the hills Some 543 cases have been registered in connection with the violent protests and 3701 persons arrested till Thursday according to police BJP observed a hartal in Pathanamthitta Friday after the body of a missing Ayyappa devotee was recovered The party alleged that he had died in police action against protesting devotees at Nilakkal However the post-mortem conducted at the Kottayam medical college hospital revealed that the pilgrim Sivadasan (60) had bled to death following serious injuries in one of his legs The Pathnamthitta SP T Narayanan said Sivadasan had come to offer prayers at the temple on October 18 and had spoken to his family the next day before returning As he did not return home his son had filed a missing complaint on October 21 The SP also refuted the allegation that man had lost his life during police action at Nilakkal on October 16 and 17 Shops and business establishments had downed shutters and buses and autorickshaws stayed off the roads in the area following the hartal Describing the BJP protest as "unnecessary" Devaswom (temple administration) Minister Kadakampally Surendran said it was only to cause difficulties to the people Even the deceased’s family has not alleged there was any foul play he told reporters Alleging that a "false campaign" was on against the police a senior official said he had died in an accident Meanwhile an office of caste-based outfit Nair Service Society (NSS) which is opposing the Supreme Court verdict allowing women of all age groups into the Sabarimala temple was vandalised in Kerala early Friday police said The office situated in Nemom near Thiruvananthapuram was allegedly pelted with stones by miscreants who destroyed its flagpole and broke the window panes of a memorial of saint-reformer Chattampi Swamy located in front of the building they said The Indian Police Service (IPS) Association of Kerala Friday condemned the verbal and digital attack against certain police officers in the state in connection with the recent Sabarimala incidents In a resolution passed at a meeting here the association said attempt has been made to "vilify" and "intimidate" police officers who carried out their duties during the recent violent protests held against the entry of women all ages into to the Sabarimala shrine 2010, I wasnt really acting,S sanctioned five Iranian entities for their work on the nations ballistic missile program and signaled that more punitive measures lay ahead in response to the Islamic Republics suppression of anti-government protests. Delhi BJP chief Manoj Tiwari described the incident as an "outcome of arrogance" of the ruling party leaders.

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Dre Forbes has published its list of the top earners in hip-hop, Fla. Bismarck police and Bismarck Public Schools considered ways SROs could be better prepared for school shootings Stugelmeyer said previouslyIn Bismarck there are six SROs at the public high schools and middle schools as well as the private Catholic high school They carry handguns but Stugelmeyer had said an AR-15 would be more beneficial in situations where they might have to shoot from far awayThe total cost for the AR-15s gun safes bulletproof vests and medical kits to treat gunshot wounds totaled more than $25000 Bismarck police and Bismarck Public Schools agreed to split the cost with no district funding being provided for the firearms purchaseThe rifles are named for the company that developed them in the 1950s and are officially called ArmaLite-15s They have been used in many of the mass shootings in the US and thus according to the New York Timesit’s called the "most beloved and most vilified rifle" in the nationRyan Repp director of content and communications for Iowa-based Brownells said company officials heard about Bismarck Police Department’s request and wanted to help"We have made donations to police departments around the country if we hear that they’re in need and we have the opportunity to help" Repp said "I don’t know that any of (our donations) were earmarked for SROs necessarily But law enforcement support is something near and dear to us"Brownells donated the AR-15s which Repp estimated were valued at about $520 each hundreds of dollars worth of custom parts and an $1800 firearm kitThe donation allowed the Bismarck Police Department to spend more on medical kits Stugelmeyer said instead of one kit that could treat one or two people now kits that can treat up to 16 will be purchased The police department already has received the AR-15s from Brownells according to Stugelmeyer This allows the rifles to get into the hands of SROs faster as the police department wouldn’t have received the city funds until January"With the support we’ll be able to get the project out quicker and we’ll be able to have a more robust medical kit that we really wouldn’t have had the budget for otherwise without the donation" he said(JAKARTA) Indonesia plans to pursue Alphabet Inc’s Google for five years of back taxes and the search giant could face a bill of more than $400 million for 2015 alone if it is found to have avoided payments a senior tax official said Muhammad Haniv head of the tax office’s special cases branch told Reuters its investigators went to Google’s local office in Indonesia on Monday The tax office alleges PT Google Indonesia paid less than 01 percent of the total income and value-added taxes it owed last year Asked to respond to Haniv’s comments Google Indonesia reiterated a statement made last week in which it said it continues to cooperate with local authorities and has paid all applicable taxes The move comes at a time when Indonesia is eager to ramp up tax collection to narrow its budget deficit and fund an ambitious infrastructure program Other governments around the world are also seeking to clamp down on what they see as egregious corporate tax avoidance Haniv added that the tax office planned to pursue other internet firms for back taxes If found guilty Google may have to pay fines of up to four times the amount it owed bringing the maximum tax bill to 55 trillion rupiah ($418 million) for 2015 Haniv said He declined to provide an estimate for the five-year period Most of its revenue generated in the country is booked at Google’s Asia Pacific headquarters in Singapore Google Asia Pacific declined to be audited in June prompting the tax office to escalate the case into a criminal one he said “Google’s argument is that they just did tax planning” Haniv said “Tax planning is legal but aggressive tax planning – to the extent that the country where the revenue is made does not get anything – is not legal” The tax office will summon directors from Google Indonesia who also hold positions at Google Asia Pacific Haniv said adding that it is working with the Indonesian police Globally it is rare for a state investigation of corporate tax structures to be escalated into a criminal case Governments hitting back Indonesia‘s move to pursue Google shows that the international tax tide might be turning said Crawford Spence a professor of accounting at Warwick Business School in Britain “In recent decades multinationals have scoured the globe looking for low tax jurisdictions effectively engaging in rate-shopping as part of tax minimisation strategies” Spence wrote in an email “Now with initiatives at the transnational level…countries are starting to develop the confidence to hit back” In January Google agreed to pay 130 million pounds ($185 million) in back taxes to settle a probe by Britain’s tax authority which had challenged the company’s low tax returns for the years since 2005 The Indonesia case is unlikely to be resolved soon as it normally takes at least three years for a court to make a decision on a tax-related criminal case said Yustinus Prastowo executive director of the Center for Indonesia Taxation Analysis Haniv said the tax office is planning to chase back taxes from other companies that deliver content through the internet (over-the-top service providers) in Indonesia The Indonesian communication and information ministry is working on a new regulation for OTT providers and the tax office has proposed that a company with a “network presence” in Indonesia should also be subject to taxation Total advertising revenue for the industry is estimated at $830 million a year with Google and Facebook Inc accounting for around 70 percent of that according to Haniv A joint study by Google and Singapore state investor Temasek released earlier this year however estimated the size of Indonesia‘s digital advertising market at $300 million for 2015 Reporting by Gayatri Suroyo and Eveline Danubrata; Additional reporting by Miyoung Kim; Editing by Edwina Gibbs and Alexander Smith Contact us at editors@timecomLast week the Brihanmumbai Municipal corporation’s (BMC’s) historic central hall saw high-decibel drama with the Shiv Sena getting its mayoral candidate elected Sena party chief Uddhav Thackeray accompanied by his wife and power centre of the party Rashmi Thackeray and son Aaditya raised their fists and congratulated new mayor Vishwanath Mahadeshwar as he took the high chair But deep inside all three of them know that they have to brace for what is going to be their toughest term in 25 years of ruling the BMC What followed was 82 BJP corporators chanting "Modi Modi" as if to boo Uddhav This was countered by 84 Sena corporators shouting slogans praising late Sena chief Bal Thackeray The 31 Congress corporators with the party’s lowest-ever tally looked helpless as though they have been forced to play the role of a scathing Opposition and their bargaining power is going south? The measure, [Reuters] Contact us at editors@time. Harrouff was found hovering over Stevens and trying to bite his face off, after an exemption came into force to avoid breaching Seoul’s tough national security law. and Cortney Tucker kiss after being married by Oakland County Clerk Lisa Brown in Pontiac,上海龙凤419Tory, And indeed if he wins Uttar Pradesh," the renowned pole vaulter and two-time Olympic champion Yelena Isinbayeva.